Cell Senescence Entries for IL24

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2018) Oct4 suppresses IR‑induced premature senescence in breast cancer cells through STAT3- and NF‑κB-mediated IL‑24 production. Int J Oncol 53(1)47-58 (PubMed)

IL24 Gene Information

HGNC symbol
IL24 
Aliases
C49A; FISP; IL-24; IL10B; mda-7; Mob-5; ST16 
Common name
interleukin 24 
Entrez Id
11009
Description
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

IL24 Ontologies

Gene Ontology
Process: GO:6915; apoptotic process
GO:7165; signal transduction
GO:8284; positive regulation of cell population proliferation
GO:8285; negative regulation of cell population proliferation
GO:30336; negative regulation of cell migration
GO:42060; wound healing
GO:42501; serine phosphorylation of STAT protein
GO:42531; positive regulation of tyrosine phosphorylation of STAT protein
GO:71222; cellular response to lipopolysaccharide
GO:71353; cellular response to interleukin-4
Cellular component: GO:5576; extracellular region
GO:5615; extracellular space
Function: GO:5515; protein binding
GO:5125; cytokine activity
Hide GO terms

Homologs of IL24 in Model Organisms

Mus musculus
Il24
Rattus norvegicus
Il24

External links

OMIM
604136
Ensembl
ENSG00000162892
Entrez Gene
11009
UniGene
744273
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IL24
GeneCards
IL24