Cell Senescence Entries for INCENP

Cell Types
Colorectal cancer, Melanoma
Cell Lines
A375P, HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

INCENP Gene Information

HGNC symbol
INCENP 
Aliases
FLJ31633 
Common name
inner centromere protein 
Entrez Id
3619
Description
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008].

INCENP Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:51301; cell division
GO:7059; chromosome segregation
GO:281; mitotic cytokinesis
GO:1902412; regulation of mitotic cytokinesis
GO:70; mitotic sister chromatid segregation
GO:6468; protein phosphorylation
GO:16572; histone phosphorylation
GO:51310; metaphase plate congression
GO:90267; positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:51257; meiotic spindle midzone assembly
GO:278; mitotic cell cycle
GO:1934; positive regulation of protein phosphorylation
GO:7052; mitotic spindle organization
GO:51256; mitotic spindle midzone assembly
GO:1901970; positive regulation of mitotic sister chromatid separation
GO:1902425; positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1903490; positive regulation of mitotic cytokinesis
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5694; chromosome
GO:16604; nuclear body
GO:30496; midbody
GO:5874; microtubule
GO:775; chromosome, centromeric region
GO:5819; spindle
GO:776; kinetochore
GO:32133; chromosome passenger complex
GO:15630; microtubule cytoskeleton
GO:5721; pericentric heterochromatin
GO:1990385; meiotic spindle midzone
GO:795; synaptonemal complex
GO:800; lateral element
GO:801; central element
GO:10369; chromocenter
Function: GO:5515; protein binding
GO:43539; protein serine/threonine kinase activator activity
Hide GO terms

Homologs of INCENP in Model Organisms

Caenorhabditis elegans
icp-1
Danio rerio
uncharacterized_F1QN
Mus musculus
Incenp
Rattus norvegicus
Incenp

External links

OMIM
604411
Ensembl
ENSG00000149503
Entrez Gene
3619
UniGene
142179
1000 Genomes
1000 Genomes
HPRD
GenAtlas
INCENP
GeneCards
INCENP