Cell Senescence Entries for ING1
- Cell Types
- Foreskin fibroblast
- Cell Lines
- HS68
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Soliman et al. (2009) ING1a expression increases during replicative senescence and induces a senescent phenotype. Aging Cell 7(6)783-94 (PubMed)
ING1 Gene Information
- HGNC symbol
- ING1
- Aliases
- p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a
- Common name
- inhibitor of growth family member 1
- Entrez Id
- 3621
- Description
- This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
ING1 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:8285; negative regulation of cell population proliferation
GO:10941; regulation of cell death
GO:30308; negative regulation of cell growth
GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:30336; negative regulation of cell migration
GO:1902459; positive regulation of stem cell population maintenance
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:1902455; negative regulation of stem cell population maintenance
GO:6606; protein import into nucleus
GO:6325; chromatin organization
Cellular component: GO:5634; nucleus
GO:16580; Sin3 complex
Hide GO termsFunction: GO:46872; metal ion binding
GO:5515; protein binding
GO:35064; methylated histone binding
Homologs of ING1 in Model Organisms
- Danio rerio
- ing1
- Drosophila melanogaster
- CG7379
- Mus musculus
- Ing1
- Rattus norvegicus
- Ing1
- Schizosaccharomyces pombe
- png2
External links
- OMIM
- 601566
- Ensembl
- ENSG00000153487
- Entrez Gene
- 3621
- UniGene
- 508725
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ING1
- GeneCards
- ING1