Cell Senescence Entries for ING2

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Pedeux et al. (2005) ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Mol Cell Biol 25(15)6639-48 (PubMed)

ING2 Gene Information

HGNC symbol
ING2 
Aliases
ING1L; p33ING2 
Common name
inhibitor of growth family member 2 
Entrez Id
3622
Description
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

ING2 Ontologies

Gene Ontology
Process: GO:42981; regulation of apoptotic process
GO:6325; chromatin organization
GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:40008; regulation of growth
GO:8285; negative regulation of cell population proliferation
GO:2000772; regulation of cellular senescence
GO:7165; signal transduction
GO:122; negative regulation of transcription by RNA polymerase II
GO:30511; positive regulation of transforming growth factor beta receptor signaling pathway
GO:1902166; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:7283; spermatogenesis
GO:31065; positive regulation of histone deacetylation
GO:30317; flagellated sperm motility
GO:7286; spermatid development
GO:30336; negative regulation of cell migration
GO:7141; male meiosis I
GO:48133; male germ-line stem cell asymmetric division
GO:72520; seminiferous tubule development
GO:2001020; regulation of response to DNA damage stimulus
GO:2001234; negative regulation of apoptotic signaling pathway
GO:1902459; positive regulation of stem cell population maintenance
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:1902455; negative regulation of stem cell population maintenance
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:16602; CCAAT-binding factor complex
GO:16580; Sin3 complex
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:5515; protein binding
GO:35064; methylated histone binding
GO:3682; chromatin binding
GO:35091; phosphatidylinositol binding
GO:44877; protein-containing complex binding
Hide GO terms

Homologs of ING2 in Model Organisms

Danio rerio
ing2
Mus musculus
Ing2
Rattus norvegicus
Ing2
Saccharomyces cerevisiae
YNG2

External links

OMIM
604215
Ensembl
ENSG00000168556
Entrez Gene
3622
UniGene
107153
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ING2
GeneCards
ING2