Cell Senescence Entries for ING5

Cell Types
Glioblastoma
Cell Lines
U87
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Zhao et al. (2017) The roles of ING5 in gliomas: a good marker for tumorigenesis and a potential target for gene therapy. Oncotarget 8(34)56558-56568 (PubMed)

ING5 Gene Information

HGNC symbol
ING5 
Aliases
FLJ23842; p28ING5 
Common name
inhibitor of growth family member 5 
Entrez Id
84289
Description
This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016].

ING5 Ontologies

Gene Ontology
Process: GO:16573; histone acetylation
GO:8285; negative regulation of cell population proliferation
GO:6325; chromatin organization
GO:43966; histone H3 acetylation
GO:45893; positive regulation of transcription, DNA-templated
GO:6260; DNA replication
GO:6473; protein acetylation
GO:6355; regulation of transcription, DNA-templated
GO:44154; histone H3-K14 acetylation
GO:43967; histone H4 acetylation
GO:43981; histone H4-K5 acetylation
GO:43982; histone H4-K8 acetylation
GO:45926; negative regulation of growth
GO:6275; regulation of DNA replication
GO:51726; regulation of cell cycle
GO:1558; regulation of cell growth
GO:16570; histone modification
GO:43983; histone H4-K12 acetylation
GO:2000278; regulation of DNA biosynthetic process
GO:43065; positive regulation of apoptotic process
GO:2001235; positive regulation of apoptotic signaling pathway
GO:50793; regulation of developmental process
GO:1903706; regulation of hemopoiesis
Cellular component: GO:5634; nucleus
GO:70776; MOZ/MORF histone acetyltransferase complex
GO:5694; chromosome
GO:123; histone acetyltransferase complex
GO:5654; nucleoplasm
Function: GO:46872; metal ion binding
GO:5515; protein binding
GO:35064; methylated histone binding
GO:3682; chromatin binding
Hide GO terms

Homologs of ING5 in Model Organisms

Danio rerio
ing5a
Mus musculus
Ing5
Rattus norvegicus
Ing5

External links

OMIM
608525
Ensembl
ENSG00000168395
Entrez Gene
84289
UniGene
529172
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ING5
GeneCards
ING5