Cell Senescence Entries for INPP4B
- Cell Types
- Mammary epithelial
- Cell Lines
- HMEC
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Gewinner et al. (2009) Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 16(2)115-25 (PubMed)
INPP4B Gene Information
- HGNC symbol
- INPP4B
- Aliases
- Common name
- inositol polyphosphate-4-phosphatase type II B
- Entrez Id
- 8821
- Description
- INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008].
INPP4B Ontologies
- Gene Ontology
-
Process: GO:6629; lipid metabolic process
GO:36092; phosphatidylinositol-3-phosphate biosynthetic process
GO:7165; signal transduction
GO:6661; phosphatidylinositol biosynthetic process
GO:43647; inositol phosphate metabolic process
GO:46855; inositol phosphate dephosphorylation
GO:46856; phosphatidylinositol dephosphorylation
GO:16311; dephosphorylation
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:16020; membrane
GO:16021; integral component of membrane
Hide GO termsFunction: GO:16787; hydrolase activity
GO:16316; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:34597; phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
GO:5515; protein binding
GO:17161; inositol-1,3,4-trisphosphate 4-phosphatase activity
GO:52828; inositol-3,4-bisphosphate 4-phosphatase activity
Homologs of INPP4B in Model Organisms
- Caenorhabditis elegans
- CELE_R01H10.7
- Danio rerio
- inpp4b
- Drosophila melanogaster
- CG33249
- Mus musculus
- Inpp4b
- Rattus norvegicus
- Inpp4b
External links
- OMIM
- 607494
- Ensembl
- ENSG00000109452
- Entrez Gene
- 8821
- UniGene
- 531403
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- INPP4B
- GeneCards
- INPP4B