Cell Senescence Entries for IRF5

Cell Types
Li Fraumeni syndrome fibroblast
Cell Lines
MDAH041
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Li et al. (2008) Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts. Mol Cancer Res 6(5)770-84 (PubMed)

IRF5 Gene Information

HGNC symbol
IRF5 
Aliases
IRF-5 
Common name
interferon regulatory factor 5 
Entrez Id
3663
Description
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016].

IRF5 Ontologies

Gene Ontology
Process: GO:6357; regulation of transcription by RNA polymerase II
GO:51607; defense response to virus
GO:19221; cytokine-mediated signaling pathway
GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:2376; immune system process
GO:45087; innate immune response
GO:6954; inflammatory response
GO:60333; interferon-gamma-mediated signaling pathway
GO:60337; type I interferon signaling pathway
GO:32727; positive regulation of interferon-alpha production
GO:32728; positive regulation of interferon-beta production
GO:32735; positive regulation of interleukin-12 production
GO:43065; positive regulation of apoptotic process
GO:32481; positive regulation of type I interferon production
GO:32494; response to peptidoglycan
GO:32495; response to muramyl dipeptide
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:785; chromatin
GO:5829; cytosol
Function: GO:3677; DNA binding
GO:976; transcription cis-regulatory region binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1990837; sequence-specific double-stranded DNA binding
GO:42802; identical protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:19901; protein kinase binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
Hide GO terms

Homologs of IRF5 in Model Organisms

Danio rerio
irf5
Mus musculus
Irf5
Rattus norvegicus
Irf5

External links

OMIM
607218
Ensembl
ENSG00000128604
Entrez Gene
3663
UniGene
521181
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IRF5
GeneCards
IRF5