Cell Senescence Entries for IRF7

Cell Types
Li Fraumeni syndrome fibroblast
Cell Lines
MDAH041
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Li et al. (2008) Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts. Mol Cancer Res 6(5)770-84 (PubMed)

IRF7 Gene Information

HGNC symbol
IRF7 
Aliases
 
Common name
interferon regulatory factor 7 
Entrez Id
3665
Description
This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021].

IRF7 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:60333; interferon-gamma-mediated signaling pathway
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:60337; type I interferon signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:32479; regulation of type I interferon production
GO:9615; response to virus
GO:32727; positive regulation of interferon-alpha production
GO:32728; positive regulation of interferon-beta production
GO:122; negative regulation of transcription by RNA polymerase II
GO:19043; establishment of viral latency
GO:50776; regulation of immune response
GO:2819; regulation of adaptive immune response
GO:34124; regulation of MyD88-dependent toll-like receptor signaling pathway
GO:39530; MDA-5 signaling pathway
GO:34127; regulation of MyD88-independent toll-like receptor signaling pathway
GO:45655; regulation of monocyte differentiation
GO:2000110; negative regulation of macrophage apoptotic process
GO:10468; regulation of gene expression
GO:16064; immunoglobulin mediated immune response
GO:32481; positive regulation of type I interferon production
GO:60340; positive regulation of type I interferon-mediated signaling pathway
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:10008; endosome membrane
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:976; transcription cis-regulatory region binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1990837; sequence-specific double-stranded DNA binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:987; cis-regulatory region sequence-specific DNA binding
Hide GO terms

Homologs of IRF7 in Model Organisms

Danio rerio
irf7
Mus musculus
Irf7
Rattus norvegicus
Irf7

In other databases

GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Irf7

External links

OMIM
605047
Ensembl
ENSG00000185507
Entrez Gene
3665
UniGene
166120
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IRF7
GeneCards
IRF7