Cell Senescence Entries for ITPR1

Cell Types
Mammary epithelial
Cell Lines
HEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wiel et al. (2016) Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence. Nat Commun 5(2)3792 (PubMed)

ITPR1 Gene Information

HGNC symbol
ITPR1 
Aliases
ACV; Insp3r1; IP3R1; PPP1R94; SCA15; SCA16; SCA29 
Common name
inositol 1,4,5-trisphosphate receptor type 1 
Entrez Id
3708
Description
This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009].

ITPR1 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:6811; ion transport
GO:6915; apoptotic process
GO:7165; signal transduction
GO:6816; calcium ion transport
GO:70588; calcium ion transmembrane transport
GO:48016; inositol phosphate-mediated signaling
GO:51209; release of sequestered calcium ion into cytosol
GO:70059; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:10506; regulation of autophagy
GO:99566; regulation of postsynaptic cytosolic calcium ion concentration
GO:1666; response to hypoxia
GO:50849; negative regulation of calcium-mediated signaling
GO:32879; regulation of localization
GO:1903779; regulation of cardiac conduction
GO:902; cell morphogenesis
GO:9791; post-embryonic development
GO:32469; endoplasmic reticulum calcium ion homeostasis
GO:42045; epithelial fluid transport
GO:50882; voluntary musculoskeletal movement
GO:51239; regulation of multicellular organismal process
GO:34220; ion transmembrane transport
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:31410; cytoplasmic vesicle
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:48471; perinuclear region of cytoplasm
GO:5886; plasma membrane
GO:30658; transport vesicle membrane
GO:16529; sarcoplasmic reticulum
GO:31095; platelet dense tubular network membrane
GO:30667; secretory granule membrane
GO:30659; cytoplasmic vesicle membrane
GO:31094; platelet dense tubular network
GO:31088; platelet dense granule membrane
GO:43231; intracellular membrane-bounded organelle
GO:12505; endomembrane system
GO:5635; nuclear envelope
GO:5637; nuclear inner membrane
GO:5730; nucleolus
GO:5955; calcineurin complex
GO:14069; postsynaptic density
GO:32991; protein-containing complex
GO:45202; synapse
GO:98685; Schaffer collateral - CA1 synapse
Function: GO:5216; ion channel activity
GO:5515; protein binding
GO:5262; calcium channel activity
GO:35091; phosphatidylinositol binding
GO:70679; inositol 1,4,5 trisphosphate binding
GO:5509; calcium ion binding
GO:5220; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:15278; calcium-release channel activity
GO:15085; calcium ion transmembrane transporter activity
GO:19855; calcium channel inhibitor activity
GO:19904; protein domain specific binding
GO:98695; inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
GO:15075; ion transmembrane transporter activity
Hide GO terms

Homologs of ITPR1 in Model Organisms

Danio rerio
itpr1
Mus musculus
Itpr1
Rattus norvegicus
Itpr1

External links

OMIM
147265
Ensembl
ENSG00000150995
Entrez Gene
3708
UniGene
715765
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ITPR1
GeneCards
ITPR1