Cell Senescence Entries for KAT5

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Zheng et al. (2013) A posttranslational modification cascade involving p38, Tip60, and PRAK mediates oncogene-induced senescence. Mol Cell 50(5)699-710 (PubMed)

KAT5 Gene Information

HGNC symbol
KAT5 
Aliases
cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP60; ZC2HC5 
Common name
lysine acetyltransferase 5 
Entrez Id
10524
Description
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].

KAT5 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:40008; regulation of growth
GO:6302; double-strand break repair
GO:16573; histone acetylation
GO:6289; nucleotide-excision repair
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902036; regulation of hematopoietic stem cell differentiation
GO:10212; response to ionizing radiation
GO:45892; negative regulation of transcription, DNA-templated
GO:132; establishment of mitotic spindle orientation
GO:10508; positive regulation of autophagy
GO:7286; spermatid development
GO:1905168; positive regulation of double-strand break repair via homologous recombination
GO:122; negative regulation of transcription by RNA polymerase II
GO:42753; positive regulation of circadian rhythm
GO:1901985; positive regulation of protein acetylation
GO:724; double-strand break repair via homologous recombination
GO:90398; cellular senescence
GO:45591; positive regulation of regulatory T cell differentiation
GO:42149; cellular response to glucose starvation
GO:42981; regulation of apoptotic process
GO:1905691; lipid droplet disassembly
GO:71392; cellular response to estradiol stimulus
GO:51726; regulation of cell cycle
GO:10867; positive regulation of triglyceride biosynthetic process
GO:43967; histone H4 acetylation
GO:43968; histone H2A acetylation
GO:32703; negative regulation of interleukin-2 production
GO:6978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:45663; positive regulation of myoblast differentiation
GO:2000779; regulation of double-strand break repair
GO:18394; peptidyl-lysine acetylation
GO:1902425; positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:43977; histone H2A-K5 acetylation
GO:43984; histone H4-K16 acetylation
GO:62033; positive regulation of mitotic sister chromatid segregation
GO:1900051; positive regulation of histone exchange
GO:6357; regulation of transcription by RNA polymerase II
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5730; nucleolus
GO:123; histone acetyltransferase complex
GO:48471; perinuclear region of cytoplasm
GO:35267; NuA4 histone acetyltransferase complex
GO:776; kinetochore
GO:97431; mitotic spindle pole
GO:786; nucleosome
GO:32777; Piccolo NuA4 histone acetyltransferase complex
GO:812; Swr1 complex
GO:5667; transcription regulator complex
Function: GO:46872; metal ion binding
GO:16740; transferase activity
GO:16746; acyltransferase activity
GO:5515; protein binding
GO:4402; histone acetyltransferase activity
GO:3713; transcription coactivator activity
GO:42393; histone binding
GO:3682; chromatin binding
GO:3712; transcription coregulator activity
GO:140297; DNA-binding transcription factor binding
GO:16407; acetyltransferase activity
GO:140065; peptide butyryltransferase activity
GO:61733; peptide-lysine-N-acetyltransferase activity
GO:43998; H2A histone acetyltransferase activity
GO:46972; histone acetyltransferase activity (H4-K16 specific)
GO:43999; histone acetyltransferase activity (H2A-K5 specific)
GO:140064; peptide crotonyltransferase activity
Hide GO terms

Homologs of KAT5 in Model Organisms

Caenorhabditis elegans
mys-1
Danio rerio
zgc:92510
Drosophila melanogaster
Tip60
Mus musculus
Kat5
Rattus norvegicus
Kat5
Saccharomyces cerevisiae
ESA1
Schizosaccharomyces pombe
mst1

External links

OMIM
601409
Ensembl
ENSG00000172977
Entrez Gene
10524
UniGene
397010
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KAT5
GeneCards
KAT5