Cell Senescence Entries for KDM1A

Cell Types
Fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Yu et al. (2018) Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell 33(2)322-336.e8 (PubMed)

KDM1A Gene Information

HGNC symbol
KDM1A 
Aliases
AOF2; BHC110; KDM1; KIAA0601; LSD1 
Common name
lysine demethylase 1A 
Entrez Id
23028
Description
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].

KDM1A Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:34720; histone H3-K4 demethylation
GO:6325; chromatin organization
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:33169; histone H3-K9 demethylation
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:45892; negative regulation of transcription, DNA-templated
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:120162; positive regulation of cold-induced thermogenesis
GO:32091; negative regulation of protein binding
GO:43518; negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:1902166; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:10569; regulation of double-strand break repair via homologous recombination
GO:32880; regulation of protein localization
GO:33184; positive regulation of histone ubiquitination
GO:34644; cellular response to UV
GO:71480; cellular response to gamma radiation
GO:2052; positive regulation of neuroblast proliferation
GO:6482; protein demethylation
GO:43392; negative regulation of DNA binding
GO:51572; negative regulation of histone H3-K4 methylation
GO:51573; negative regulation of histone H3-K9 methylation
GO:55001; muscle cell development
GO:60765; regulation of androgen receptor signaling pathway
GO:90308; regulation of DNA methylation-dependent heterochromatin assembly
GO:2000179; positive regulation of neural precursor cell proliferation
GO:2000648; positive regulation of stem cell proliferation
GO:380; alternative mRNA splicing, via spliceosome
GO:10976; positive regulation of neuron projection development
GO:14070; response to organic cyclic compound
GO:21987; cerebral cortex development
GO:35563; positive regulation of chromatin binding
GO:42551; neuron maturation
GO:45793; positive regulation of cell size
GO:46098; guanine metabolic process
GO:60992; response to fungicide
GO:71320; cellular response to cAMP
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:781; chromosome, telomeric region
GO:32991; protein-containing complex
GO:785; chromatin
GO:5667; transcription regulator complex
GO:1990391; DNA repair complex
Function: GO:5515; protein binding
GO:16491; oxidoreductase activity
GO:50660; flavin adenine dinucleotide binding
GO:32453; histone demethylase activity (H3-K4 specific)
GO:30374; nuclear receptor coactivator activity
GO:3682; chromatin binding
GO:32454; histone demethylase activity (H3-K9 specific)
GO:43426; MRF binding
GO:32452; histone demethylase activity
GO:19899; enzyme binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:50681; androgen receptor binding
GO:2039; p53 binding
GO:32451; demethylase activity
GO:61752; telomeric repeat-containing RNA binding
GO:140297; DNA-binding transcription factor binding
GO:1990841; promoter-specific chromatin binding
Hide GO terms

Homologs of KDM1A in Model Organisms

Caenorhabditis elegans
lsd-1
Danio rerio
kdm1a
Drosophila melanogaster
Su(var)3-3
Mus musculus
Kdm1a
Rattus norvegicus
Kdm1a

In other databases

CellAge gene expression
  • This gene is present as KDM1A

External links

OMIM
609132
Ensembl
ENSG00000004487
Entrez Gene
23028
UniGene
591518
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KDM1A
GeneCards
KDM1A