Cell Senescence Entries for KDM2B

Cell Types
Embryonic kidney, Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, HEK293T, IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Tzatsos et al. (2011) Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells. J Biol Chem 286(38)33061-9 (PubMed)

KDM2B Gene Information

HGNC symbol
KDM2B 
Aliases
CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2 
Common name
lysine demethylase 2B 
Entrez Id
84678
Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].

KDM2B Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:43524; negative regulation of neuron apoptotic process
GO:6482; protein demethylation
GO:70544; histone H3-K36 demethylation
GO:35518; histone H2A monoubiquitination
GO:30901; midbrain development
GO:48596; embryonic camera-type eye morphogenesis
GO:7283; spermatogenesis
GO:30902; hindbrain development
GO:30900; forebrain development
GO:21555; midbrain-hindbrain boundary morphogenesis
GO:21592; fourth ventricle development
GO:21670; lateral ventricle development
GO:21678; third ventricle development
GO:21993; initiation of neural tube closure
GO:2000178; negative regulation of neural precursor cell proliferation
GO:30307; positive regulation of cell growth
GO:1902459; positive regulation of stem cell population maintenance
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:5730; nucleolus
GO:31519; PcG protein complex
Function: GO:3723; RNA binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:3677; DNA binding
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:19843; rRNA binding
GO:32452; histone demethylase activity
GO:45322; unmethylated CpG binding
GO:3712; transcription coregulator activity
GO:51864; histone demethylase activity (H3-K36 specific)
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Hide GO terms

Homologs of KDM2B in Model Organisms

Mus musculus
Kdm2b
Rattus norvegicus
Kdm2b

External links

OMIM
609078
Ensembl
ENSG00000089094
Entrez Gene
84678
UniGene
524800
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KDM2B
GeneCards
KDM2B