The KDR gene and its putative association with human ageing

Cell Types

Glioblastoma

Cell Lines

U-373MG

Cancer Cell?

Yes

Method

Knockdown

Type of senescence

Unclear

Senescence Effect

Inhibits

Primary Reference

Jones et al. (2017) Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. Neuro Oncol 18(5)667-78 (PubMed)

HGNC symbol

KDR

Aliases

CD309; FLK1; VEGFR; VEGFR2

Common name

kinase insert domain receptor

Entrez Id

3791

Description

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009].

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:30154; cell differentiation
GO:1934; positive regulation of protein phosphorylation
GO:1525; angiogenesis
GO:8284; positive regulation of cell population proliferation
GO:46777; protein autophosphorylation
GO:48010; vascular endothelial growth factor receptor signaling pathway
GO:45766; positive regulation of angiogenesis
GO:16477; cell migration
GO:30335; positive regulation of cell migration
GO:43410; positive regulation of MAPK cascade
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:1938; positive regulation of endothelial cell proliferation
GO:10595; positive regulation of endothelial cell migration
GO:90050; positive regulation of cell migration involved in sprouting angiogenesis
GO:2000352; negative regulation of endothelial cell apoptotic process
GO:35924; cellular response to vascular endothelial growth factor stimulus
GO:10629; negative regulation of gene expression
GO:1569; branching involved in blood vessel morphogenesis
GO:2042; cell migration involved in sprouting angiogenesis
GO:51894; positive regulation of focal adhesion assembly
GO:2244; hematopoietic progenitor cell differentiation
GO:33674; positive regulation of kinase activity
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:16239; positive regulation of macroautophagy
GO:1570; vasculogenesis
GO:35584; calcium-mediated signaling using intracellular calcium source
GO:18108; peptidyl-tyrosine phosphorylation
GO:38083; peptidyl-tyrosine autophosphorylation
GO:8360; regulation of cell shape
GO:38033; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:70371; ERK1 and ERK2 cascade
GO:51901; positive regulation of mitochondrial depolarization
GO:90141; positive regulation of mitochondrial fission
GO:50927; positive regulation of positive chemotaxis
GO:35162; embryonic hemopoiesis
GO:2001214; positive regulation of vasculogenesis
GO:36324; vascular endothelial growth factor receptor-2 signaling pathway
GO:38084; vascular endothelial growth factor signaling pathway
GO:61042; vascular wound healing
GO:3158; endothelium development
GO:43491; protein kinase B signaling
GO:1541; ovarian follicle development
GO:1945; lymph vessel development
GO:2053; positive regulation of mesenchymal cell proliferation
GO:3157; endocardium development
GO:30097; hemopoiesis
GO:30324; lung development
GO:30513; positive regulation of BMP signaling pathway
GO:43129; surfactant homeostasis
GO:45165; cell fate commitment
GO:45446; endothelial cell differentiation
GO:48286; lung alveolus development
GO:48469; cell maturation
GO:48597; post-embryonic camera-type eye morphogenesis
GO:48754; branching morphogenesis of an epithelial tube
GO:50679; positive regulation of epithelial cell proliferation
GO:51770; positive regulation of nitric-oxide synthase biosynthetic process
GO:55074; calcium ion homeostasis
GO:1901532; regulation of hematopoietic progenitor cell differentiation
GO:1903010; regulation of bone development
GO:1904881; cellular response to hydrogen sulfide

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:5783; endoplasmic reticulum
GO:5886; plasma membrane
GO:5768; endosome
GO:5576; extracellular region
GO:30054; cell junction
GO:45121; membrane raft
GO:5769; early endosome
GO:5887; integral component of plasma membrane
GO:43235; receptor complex
GO:97443; sorting endosome
GO:9897; external side of plasma membrane
GO:9986; cell surface
GO:71944; cell periphery

Function:

GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:5021; vascular endothelial growth factor-activated receptor activity
GO:19838; growth factor binding
GO:51879; Hsp90 protein binding
GO:45296; cadherin binding
GO:5178; integrin binding
GO:38085; vascular endothelial growth factor binding

Hide GO terms

Danio rerio

Mus musculus

Rattus norvegicus

OMIM

Ensembl

Entrez Gene