Cell Senescence Entries for KEAP1

Cell Types
Aortic endothelial
Cell Lines
HAEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Kopacz et al. (2020) Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells. Redox Biol 28(2)101304 (PubMed)

KEAP1 Gene Information

HGNC symbol
KEAP1 
Aliases
INrf2; KIAA0132; KLHL19; MGC10630; MGC1114; MGC20887; MGC4407; MGC9454 
Common name
kelch like ECH associated protein 1 
Entrez Id
9817
Description
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].

KEAP1 Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:6511; ubiquitin-dependent protein catabolic process
GO:1701; in utero embryonic development
GO:6355; regulation of transcription, DNA-templated
GO:10506; regulation of autophagy
GO:34599; cellular response to oxidative stress
GO:45604; regulation of epidermal cell differentiation
GO:71353; cellular response to interleukin-4
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:42994; cytoplasmic sequestering of transcription factor
Cellular component: GO:31463; Cul3-RING ubiquitin ligase complex
GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:34451; centriolar satellite
GO:5783; endoplasmic reticulum
GO:5884; actin filament
GO:16234; inclusion body
GO:32991; protein-containing complex
GO:30496; midbody
Function: GO:5515; protein binding
GO:8134; transcription factor binding
GO:42802; identical protein binding
GO:97718; disordered domain specific binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
Hide GO terms

Homologs of KEAP1 in Model Organisms

Danio rerio
keap1b
Drosophila melanogaster
Keap1
Mus musculus
Keap1
Rattus norvegicus
Keap1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Keap1

External links

OMIM
606016
Ensembl
ENSG00000079999
Entrez Gene
9817
UniGene
465870
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KEAP1
GeneCards
KEAP1