Cell Senescence Entries for KIF11
- Cell Types
- Colorectal cancer, Melanoma
- Cell Lines
- A375P, HCT116
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)
KIF11 Gene Information
- HGNC symbol
- KIF11
- Aliases
- Eg5; HKSP; KNSL1; TRIP5
- Common name
- kinesin family member 11
- Entrez Id
- 3832
- Description
- This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008].
KIF11 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:51301; cell division
GO:7018; microtubule-based movement
GO:90307; mitotic spindle assembly
GO:46602; regulation of mitotic centrosome separation
GO:278; mitotic cell cycle
GO:7051; spindle organization
GO:7052; mitotic spindle organization
GO:7100; mitotic centrosome separation
GO:51225; spindle assembly
Cellular component: GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5874; microtubule
GO:16020; membrane
GO:32991; protein-containing complex
GO:5829; cytosol
GO:72686; mitotic spindle
GO:5819; spindle
GO:5634; nucleus
GO:922; spindle pole
GO:5871; kinesin complex
GO:5876; spindle microtubule
Hide GO termsFunction: GO:166; nucleotide binding
GO:5524; ATP binding
GO:3774; cytoskeletal motor activity
GO:8017; microtubule binding
GO:3777; microtubule motor activity
GO:5515; protein binding
GO:19901; protein kinase binding
GO:8574; plus-end-directed microtubule motor activity
Homologs of KIF11 in Model Organisms
- Caenorhabditis elegans
- bmk-1
- Danio rerio
- kif11
- Drosophila melanogaster
- Klp61F
- Mus musculus
- Kif11
- Rattus norvegicus
- Kif11
- Saccharomyces cerevisiae
- KIP1
- Schizosaccharomyces pombe
- cut7
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as bmk-1
- CellAge gene expression
- This gene is present as KIF11
External links
- OMIM
- 148760
- Ensembl
- ENSG00000138160
- Entrez Gene
- 3832
- UniGene
- 8878
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- KIF11
- GeneCards
- KIF11