The KLF4 gene and its putative association with human ageing

Cell Types

Colon cancer, Stomach cancer

Cell Lines

AGS, SW480

Cancer Cell?

Yes

Method

Overexpression

Type of senescence

Oncogene-induced

Senescence Effect

Induces

Primary Reference

Xu et al. (2018) Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway. Oncotarget 7(37)60290-60302 (PubMed)

HGNC symbol

KLF4

Aliases

EZF; GKLF

Common name

Kruppel like factor 4

Entrez Id

9314

Description

This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].

Gene Ontology

Process:

GO:10628; positive regulation of gene expression
GO:45892; negative regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45595; regulation of cell differentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:8285; negative regulation of cell population proliferation
GO:51973; positive regulation of telomerase activity
GO:10629; negative regulation of gene expression
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:2357; defense response to tumor cell
GO:16525; negative regulation of angiogenesis
GO:32270; positive regulation of cellular protein metabolic process
GO:1903672; positive regulation of sprouting angiogenesis
GO:50728; negative regulation of inflammatory response
GO:32088; negative regulation of NF-kappaB transcription factor activity
GO:6351; transcription, DNA-templated
GO:7500; mesodermal cell fate determination
GO:9913; epidermal cell differentiation
GO:10033; response to organic substance
GO:10467; gene expression
GO:19827; stem cell population maintenance
GO:30154; cell differentiation
GO:30336; negative regulation of cell migration
GO:31077; post-embryonic camera-type eye development
GO:32526; response to retinoic acid
GO:32717; negative regulation of interleukin-8 production
GO:34115; negative regulation of heterotypic cell-cell adhesion
GO:35166; post-embryonic hemopoiesis
GO:42127; regulation of cell population proliferation
GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:45429; positive regulation of nitric oxide biosynthetic process
GO:45444; fat cell differentiation
GO:46985; positive regulation of hemoglobin biosynthetic process
GO:48679; regulation of axon regeneration
GO:48730; epidermis morphogenesis
GO:51247; positive regulation of protein metabolic process
GO:60070; canonical Wnt signaling pathway
GO:60761; negative regulation of response to cytokine stimulus
GO:71363; cellular response to growth factor stimulus
GO:71499; cellular response to laminar fluid shear stress
GO:90051; negative regulation of cell migration involved in sprouting angiogenesis
GO:120222; regulation of blastocyst development
GO:1904798; positive regulation of core promoter binding
GO:1904998; negative regulation of leukocyte adhesion to arterial endothelial cell
GO:1990830; cellular response to leukemia inhibitory factor
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:2000342; negative regulation of chemokine (C-X-C motif) ligand 2 production

Cellular component:

GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:15630; microtubule cytoskeleton
GO:785; chromatin
GO:791; euchromatin
GO:5667; transcription regulator complex
GO:5737; cytoplasm

Function:

GO:46872; metal ion binding
GO:3677; DNA binding
GO:8270; zinc ion binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:1010; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
GO:8013; beta-catenin binding
GO:43565; sequence-specific DNA binding
GO:1990841; promoter-specific chromatin binding

Hide GO terms

Danio rerio

klf4b

Drosophila melanogaster

Mus musculus

Rattus norvegicus

OMIM

Ensembl