Cell Senescence Entries for LATS2
- Cell Types
- Ovarian epithelial
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockout
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Primary Reference
- He et al. (2020) YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis. EMBO Rep 20(3)117-26 (PubMed)
LATS2 Gene Information
- HGNC symbol
- LATS2
- Aliases
- Common name
- large tumor suppressor kinase 2
- Entrez Id
- 26524
- Description
- This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008].
LATS2 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:35556; intracellular signal transduction
GO:9755; hormone-mediated signaling pathway
GO:18105; peptidyl-serine phosphorylation
GO:43065; positive regulation of apoptotic process
GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:82; G1/S transition of mitotic cell cycle
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:17015; regulation of transforming growth factor beta receptor signaling pathway
GO:35329; hippo signaling
GO:46620; regulation of organ growth
GO:1900181; negative regulation of protein localization to nucleus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:34451; centriolar satellite
GO:5815; microtubule organizing center
GO:922; spindle pole
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
Homologs of LATS2 in Model Organisms
- Danio rerio
- lats2
- Drosophila melanogaster
- wts
- Mus musculus
- Lats2
- Rattus norvegicus
- Lats2
- Saccharomyces cerevisiae
- FPK1
External links
- OMIM
- 604861
- Ensembl
- ENSG00000150457
- Entrez Gene
- 26524
- UniGene
- 78960
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- LATS2
- GeneCards
- LATS2