Cell Senescence Entries for LATS2

Cell Types
Ovarian epithelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
He et al. (2020) YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis. EMBO Rep 20(3)117-26 (PubMed)

LATS2 Gene Information

HGNC symbol
LATS2 
Aliases
 
Common name
large tumor suppressor kinase 2 
Entrez Id
26524
Description
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008].

LATS2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:35556; intracellular signal transduction
GO:9755; hormone-mediated signaling pathway
GO:18105; peptidyl-serine phosphorylation
GO:43065; positive regulation of apoptotic process
GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:82; G1/S transition of mitotic cell cycle
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:17015; regulation of transforming growth factor beta receptor signaling pathway
GO:35329; hippo signaling
GO:46620; regulation of organ growth
GO:1900181; negative regulation of protein localization to nucleus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:34451; centriolar satellite
GO:5815; microtubule organizing center
GO:922; spindle pole
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
Hide GO terms

Homologs of LATS2 in Model Organisms

Danio rerio
lats2
Drosophila melanogaster
wts
Mus musculus
Lats2
Rattus norvegicus
Lats2
Saccharomyces cerevisiae
FPK1

External links

OMIM
604861
Ensembl
ENSG00000150457
Entrez Gene
26524
UniGene
78960
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LATS2
GeneCards
LATS2