Cell Senescence Entries for LBR

Cell Types
Cervical cancer
Cell Lines
HeLa, TIG-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Arai et al. (2019) Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells. Mech Ageing Dev 178(2)25-32 (PubMed)

LBR Gene Information

HGNC symbol
LBR 
Aliases
DHCR14B; TDRD18 
Common name
lamin B receptor 
Entrez Id
3930
Description
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].

LBR Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6694; steroid biosynthetic process
GO:6695; cholesterol biosynthetic process
GO:8202; steroid metabolic process
GO:8203; cholesterol metabolic process
GO:16126; sterol biosynthetic process
GO:30223; neutrophil differentiation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:31965; nuclear membrane
GO:5637; nuclear inner membrane
GO:5635; nuclear envelope
GO:5639; integral component of nuclear inner membrane
Function: GO:3723; RNA binding
GO:16491; oxidoreductase activity
GO:3677; DNA binding
GO:5515; protein binding
GO:16628; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:50613; delta14-sterol reductase activity
GO:70402; NADPH binding
GO:16627; oxidoreductase activity, acting on the CH-CH group of donors
GO:70087; chromo shadow domain binding
GO:5521; lamin binding
Hide GO terms

Homologs of LBR in Model Organisms

Danio rerio
lbr
Mus musculus
Lbr
Rattus norvegicus
Lbr

In other databases

CellAge gene expression
  • This gene is present as LBR

External links

OMIM
600024
Ensembl
ENSG00000143815
Entrez Gene
3930
UniGene
735694
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LBR
GeneCards
LBR