Cell Senescence Entries for LCN2

Cell Types
Mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Bahmani et al. (2015) Lipocalin 2 decreases senescence of bone marrow-derived mesenchymal stem cells under sub-lethal doses of oxidative stress. Cell Stress Chaperones 19(5)685-93 (PubMed)

LCN2 Gene Information

HGNC symbol
LCN2 
Aliases
24p3; NGAL 
Common name
lipocalin 2 
Entrez Id
3934
Description
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015].

LCN2 Ontologies

Gene Ontology
Process: GO:6811; ion transport
GO:6915; apoptotic process
GO:2376; immune system process
GO:45087; innate immune response
GO:42742; defense response to bacterium
GO:55072; iron ion homeostasis
GO:120162; positive regulation of cold-induced thermogenesis
GO:15891; siderophore transport
GO:97577; sequestering of iron ion
Cellular component: GO:31410; cytoplasmic vesicle
GO:5576; extracellular region
GO:5615; extracellular space
GO:60205; cytoplasmic vesicle lumen
GO:70062; extracellular exosome
GO:35580; specific granule lumen
Function: GO:5515; protein binding
GO:36094; small molecule binding
GO:5506; iron ion binding
GO:42802; identical protein binding
GO:1903981; enterobactin binding
Hide GO terms

Homologs of LCN2 in Model Organisms

Mus musculus
Lcn2
Rattus norvegicus
Lcn2

External links

OMIM
600181
Ensembl
ENSG00000148346
Entrez Gene
3934
UniGene
204238
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LCN2
GeneCards
LCN2