Cell Senescence Entries for LGALS3

Cell Types
Gastric cancer
Cell Lines
AGS, KATO-III, MKN28, SNU-1, SNU-16, SNU-216, SNU-5, SNU-601, SNU-638, SNU-668, SNU-719, YCC-2
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2015) Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress. Cell Death Differ 21(11)1769-79 (PubMed)

LGALS3 Gene Information

HGNC symbol
LGALS3 
Aliases
GALIG; LGALS2; MAC-2 
Common name
galectin 3 
Entrez Id
3958
Description
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014].

LGALS3 Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:30154; cell differentiation
GO:2376; immune system process
GO:45087; innate immune response
GO:2548; monocyte chemotaxis
GO:30593; neutrophil chemotaxis
GO:48245; eosinophil chemotaxis
GO:30855; epithelial cell differentiation
GO:50918; positive chemotaxis
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
GO:71677; positive regulation of mononuclear cell migration
GO:1903078; positive regulation of protein localization to plasma membrane
GO:31334; positive regulation of protein-containing complex assembly
GO:50860; negative regulation of T cell receptor signaling pathway
GO:90280; positive regulation of calcium ion import
GO:48246; macrophage chemotaxis
GO:42129; regulation of T cell proliferation
GO:45806; negative regulation of endocytosis
GO:70232; regulation of T cell apoptotic process
GO:71674; mononuclear cell migration
GO:1902041; regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903614; negative regulation of protein tyrosine phosphatase activity
GO:2000521; negative regulation of immunological synapse formation
GO:2001189; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Cellular component: GO:5654; nucleoplasm
GO:5829; cytosol
GO:5737; cytoplasm
GO:5634; nucleus
GO:5681; spliceosomal complex
GO:16020; membrane
GO:5743; mitochondrial inner membrane
GO:5576; extracellular region
GO:5615; extracellular space
GO:5886; plasma membrane
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:30667; secretory granule membrane
GO:9986; cell surface
GO:101003; ficolin-1-rich granule membrane
GO:1772; immunological synapse
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:30246; carbohydrate binding
GO:19863; IgE binding
GO:19903; protein phosphatase binding
GO:42056; chemoattractant activity
GO:43236; laminin binding
GO:4864; protein phosphatase inhibitor activity
Hide GO terms

Homologs of LGALS3 in Model Organisms

Caenorhabditis elegans
lec-7
Danio rerio
si:ch211-67f24.5
Mus musculus
Lgals3
Rattus norvegicus
Lgals3

In other databases

GenAge microarray genes
  • This gene is present as LGALS3

External links

OMIM
153619
Ensembl
ENSG00000131981
Entrez Gene
3958
UniGene
531081
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LGALS3
GeneCards
LGALS3