Cell Senescence Entries for LIN9
- Cell Types
- Foreskin fibroblast
- Cell Lines
- BJ
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Hauser et al. (2012) Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth. Oncogene 31(14)1859-68 (PubMed)
LIN9 Gene Information
- HGNC symbol
- LIN9
- Aliases
- TGS
- Common name
- lin-9 DREAM MuvB core complex component
- Entrez Id
- 286826
- Description
- This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
LIN9 Ontologies
- Gene Ontology
-
Process: GO:6351; transcription, DNA-templated
GO:7049; cell cycle
GO:71897; DNA biosynthetic process
GO:6357; regulation of transcription by RNA polymerase II
GO:51726; regulation of cell cycle
GO:3; reproduction
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:17053; transcription repressor complex
Hide GO termsFunction: GO:5515; protein binding
GO:3677; DNA binding
Homologs of LIN9 in Model Organisms
- Caenorhabditis elegans
- lin-9
- Danio rerio
- LOC100330674
- Drosophila melanogaster
- aly
- Mus musculus
- Lin9
- Rattus norvegicus
- Lin9
External links
- OMIM
- 609375
- Ensembl
- ENSG00000183814
- Entrez Gene
- 286826
- UniGene
- 120817
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- LIN9
- GeneCards
- LIN9