Cell Senescence Entries for LMNA

Cell Types
Fibroblast, Foreskin fibroblast
Cell Lines
AG08470, BJ
Cancer Cell?
No
Method
Mutation
Type of senescence
Unclear
Senescence Effect
Unclear
Primary Reference
Wheaton et al. (2017) Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome. Mol Cell Biol 37(14)117-26 (PubMed)

LMNA Gene Information

HGNC symbol
LMNA 
Aliases
CMD1A; HGPS; LGMD1B; LMN1; LMNL1; MADA; PRO1 
Common name
lamin A/C 
Entrez Id
4000
Description
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012].

LMNA Ontologies

Gene Ontology
Process: GO:7517; muscle organ development
GO:34504; protein localization to nucleus
GO:71456; cellular response to hypoxia
GO:32204; regulation of telomere maintenance
GO:8285; negative regulation of cell population proliferation
GO:30334; regulation of cell migration
GO:30951; establishment or maintenance of microtubule cytoskeleton polarity
GO:90343; positive regulation of cell aging
GO:1903243; negative regulation of cardiac muscle hypertrophy in response to stress
GO:1990683; DNA double-strand break attachment to nuclear envelope
GO:34613; cellular protein localization
GO:6606; protein import into nucleus
GO:6997; nucleus organization
GO:6998; nuclear envelope organization
GO:10628; positive regulation of gene expression
GO:31647; regulation of protein stability
GO:55015; ventricular cardiac muscle cell development
GO:72201; negative regulation of mesenchymal cell proliferation
GO:90201; negative regulation of release of cytochrome c from mitochondria
GO:1900114; positive regulation of histone H3-K9 trimethylation
GO:1900180; regulation of protein localization to nucleus
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:5635; nuclear envelope
GO:31965; nuclear membrane
GO:5654; nucleoplasm
GO:48471; perinuclear region of cytoplasm
GO:5882; intermediate filament
GO:16363; nuclear matrix
GO:5829; cytosol
GO:35861; site of double-strand break
GO:5652; nuclear lamina
GO:5638; lamin filament
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:5198; structural molecule activity
Hide GO terms

Homologs of LMNA in Model Organisms

Caenorhabditis elegans
lmn-1
Danio rerio
lmna
Drosophila melanogaster
LamC
Mus musculus
Lmna
Rattus norvegicus
Lmna

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as lmn-1
  • A homolog of this gene for Mus musculus is present as Lmna
GenAge human genes
  • This gene is present as LMNA
LongevityMap
  • This gene is present as LMNA

External links

OMIM
150330
Ensembl
ENSG00000160789
Entrez Gene
4000
UniGene
706897
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LMNA
GeneCards
LMNA