Cell Senescence Entries for LOX

Cell Types
Epithelial
Cell Lines
HEC
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Wiel et al. (2014) Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death Dis 4(2)e855 (PubMed)

LOX Gene Information

HGNC symbol
LOX 
Aliases
 
Common name
lysyl oxidase 
Entrez Id
4015
Description
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016].

LOX Ontologies

Gene Ontology
Process: GO:18057; peptidyl-lysine oxidation
GO:1568; blood vessel development
GO:1649; osteoblast differentiation
GO:1932; regulation of protein phosphorylation
GO:7507; heart development
GO:9410; response to xenobiotic stimulus
GO:9725; response to hormone
GO:10468; regulation of gene expression
GO:16202; regulation of striated muscle tissue development
GO:17015; regulation of transforming growth factor beta receptor signaling pathway
GO:18158; protein oxidation
GO:30199; collagen fibril organization
GO:30282; bone mineralization
GO:30324; lung development
GO:35791; platelet-derived growth factor receptor-beta signaling pathway
GO:35904; aorta development
GO:35905; ascending aorta development
GO:35906; descending aorta development
GO:42060; wound healing
GO:42981; regulation of apoptotic process
GO:43491; protein kinase B signaling
GO:45652; regulation of megakaryocyte differentiation
GO:46716; muscle cell cellular homeostasis
GO:48251; elastic fiber assembly
GO:48514; blood vessel morphogenesis
GO:48545; response to steroid hormone
GO:55001; muscle cell development
GO:60326; cell chemotaxis
GO:61448; connective tissue development
GO:71310; cellular response to organic substance
GO:71897; DNA biosynthetic process
GO:1900120; regulation of receptor binding
GO:1903010; regulation of bone development
GO:1990869; cellular response to chemokine
GO:2000586; regulation of platelet-derived growth factor receptor-beta signaling pathway
GO:6464; cellular protein modification process
Cellular component: GO:5576; extracellular region
GO:5615; extracellular space
GO:5581; collagen trimer
GO:5634; nucleus
GO:31012; extracellular matrix
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:5507; copper ion binding
GO:4720; protein-lysine 6-oxidase activity
GO:16641; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:5518; collagen binding
Hide GO terms

Homologs of LOX in Model Organisms

Danio rerio
lox
Mus musculus
Lox
Rattus norvegicus
Lox

In other databases

LongevityMap
  • This gene is present as LOX
CellAge gene expression
  • This gene is present as LOX

External links

OMIM
153455
Ensembl
ENSG00000113083
Entrez Gene
4015
UniGene
102267
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LOX
GeneCards
LOX