Cell Senescence Entries for LOXL2

Cell Types
Epithelial
Cell Lines
HEC
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Wiel et al. (2014) Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death Dis 4(2)e855 (PubMed)

LOXL2 Gene Information

HGNC symbol
LOXL2 
Aliases
LOR; WS9-14 
Common name
lysyl oxidase like 2 
Entrez Id
4017
Description
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008].

LOXL2 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:122; negative regulation of transcription by RNA polymerase II
GO:30199; collagen fibril organization
GO:6897; endocytosis
GO:22900; electron transport chain
GO:6464; cellular protein modification process
GO:2040; sprouting angiogenesis
GO:1666; response to hypoxia
GO:18057; peptidyl-lysine oxidation
GO:7155; cell adhesion
GO:32332; positive regulation of chondrocyte differentiation
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:43542; endothelial cell migration
GO:1935; endothelial cell proliferation
GO:1837; epithelial to mesenchymal transition
GO:70828; heterochromatin organization
GO:46688; response to copper ion
GO:7568; aging
GO:1902455; negative regulation of stem cell population maintenance
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5576; extracellular region
GO:785; chromatin
GO:5694; chromosome
GO:5615; extracellular space
GO:5604; basement membrane
GO:62023; collagen-containing extracellular matrix
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5509; calcium ion binding
GO:5515; protein binding
GO:5044; scavenger receptor activity
GO:5507; copper ion binding
GO:4720; protein-lysine 6-oxidase activity
GO:16641; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:9055; electron transfer activity
GO:70492; oligosaccharide binding
Hide GO terms

Homologs of LOXL2 in Model Organisms

Danio rerio
loxl2b
Mus musculus
Loxl2
Rattus norvegicus
Loxl2

In other databases

CellAge gene expression
  • This gene is present as LOXL2

External links

OMIM
606663
Ensembl
ENSG00000134013
Entrez Gene
4017
UniGene
626637
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LOXL2
GeneCards
LOXL2