Cell Senescence Entries for LPAR1

Cell Types
B lymphoblast
Cell Lines
IM-9
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Kanehira et al. (2017) An Lysophosphatidic Acid Receptors 1 and 3 Axis Governs Cellular Senescence of Mesenchymal Stromal Cells and Promotes Growth and Vascularization of Multiple Myeloma. Stem Cells 35(3)739-753 (PubMed)

LPAR1 Gene Information

HGNC symbol
LPAR1 
Aliases
edg-2; EDG2; Gpcr26; LPA1; Mrec1.3; rec.1.3; vzg-1 
Common name
lysophosphatidic acid receptor 1 
Entrez Id
1902
Description
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020].

LPAR1 Ontologies

Gene Ontology
Process: GO:7186; G protein-coupled receptor signaling pathway
GO:7193; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:7165; signal transduction
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:43410; positive regulation of MAPK cascade
GO:7189; adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:8360; regulation of cell shape
GO:51482; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:60326; cell chemotaxis
GO:51496; positive regulation of stress fiber assembly
GO:22008; neurogenesis
GO:10977; negative regulation of neuron projection development
GO:7204; positive regulation of cytosolic calcium ion concentration
GO:19222; regulation of metabolic process
GO:7202; activation of phospholipase C activity
GO:35025; positive regulation of Rho protein signal transduction
GO:7420; brain development
GO:10942; positive regulation of cell death
GO:14003; oligodendrocyte development
GO:21549; cerebellum development
GO:21554; optic nerve development
GO:22038; corpus callosum development
GO:32060; bleb assembly
GO:42552; myelination
GO:43065; positive regulation of apoptotic process
GO:43951; negative regulation of cAMP-mediated signaling
GO:60999; positive regulation of dendritic spine development
GO:71453; cellular response to oxygen levels
GO:71673; positive regulation of smooth muscle cell chemotaxis
GO:1904566; cellular response to 1-oleoyl-sn-glycerol 3-phosphate
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5768; endosome
GO:9986; cell surface
GO:5737; cytoplasm
GO:5887; integral component of plasma membrane
GO:30139; endocytic vesicle
GO:43005; neuron projection
GO:43025; neuronal cell body
GO:43197; dendritic spine
GO:43198; dendritic shaft
Function: GO:4930; G protein-coupled receptor activity
GO:8289; lipid binding
GO:5515; protein binding
GO:70915; lysophosphatidic acid receptor activity
GO:35727; lysophosphatidic acid binding
GO:1965; G-protein alpha-subunit binding
GO:5543; phospholipid binding
GO:30165; PDZ domain binding
Hide GO terms

Homologs of LPAR1 in Model Organisms

Danio rerio
lpar1
Mus musculus
Lpar1
Rattus norvegicus
Lpar1

External links

OMIM
602282
Ensembl
ENSG00000198121
Entrez Gene
1902
UniGene
738834
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LPAR1
GeneCards
LPAR1