Cell Senescence Entries for LPAR3

Cell Types
B lymphoblast, Ovarian surface epithelial
Cell Lines
IM-9, IOSE-80
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kanehira et al. (2017) An Lysophosphatidic Acid Receptors 1 and 3 Axis Governs Cellular Senescence of Mesenchymal Stromal Cells and Promotes Growth and Vascularization of Multiple Myeloma. Stem Cells 35(3)739-753 (PubMed)

LPAR3 Gene Information

HGNC symbol
LPAR3 
Aliases
Edg-7; EDG7; HOFNH30; LP-A3; LPA3; RP4-678I3 
Common name
lysophosphatidic acid receptor 3 
Entrez Id
23566
Description
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008].

LPAR3 Ontologies

Gene Ontology
Process: GO:7186; G protein-coupled receptor signaling pathway
GO:7165; signal transduction
GO:7189; adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:7268; chemical synaptic transmission
GO:7204; positive regulation of cytosolic calcium ion concentration
GO:19222; regulation of metabolic process
GO:7187; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:10467; gene expression
GO:32060; bleb assembly
GO:43410; positive regulation of MAPK cascade
GO:48672; positive regulation of collateral sprouting
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:45202; synapse
GO:5737; cytoplasm
GO:5887; integral component of plasma membrane
GO:30424; axon
Function: GO:4930; G protein-coupled receptor activity
GO:5515; protein binding
GO:70915; lysophosphatidic acid receptor activity
GO:8289; lipid binding
Hide GO terms

Homologs of LPAR3 in Model Organisms

Mus musculus
Lpar3
Rattus norvegicus
Lpar3

External links

OMIM
605106
Ensembl
ENSG00000171517
Entrez Gene
23566
UniGene
674915
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LPAR3
GeneCards
LPAR3