Cell Senescence Entries for LRRK2

Cell Types
Bone marrow neuroblastoma
Cell Lines
SH-SY5Y
Cancer Cell?
Yes
Method
Mutation
Type of senescence
Unclear
Senescence Effect
Unclear
Primary Reference
Ho et al. (2020) Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein. Cell Cycle 18(4)467-475 (PubMed)

LRRK2 Gene Information

HGNC symbol
LRRK2 
Aliases
DKFZp434H2111; FLJ45829; PARK8; RIPK7; ROCO2 
Common name
leucine rich repeat kinase 2 
Entrez Id
120892
Description
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].

LRRK2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:30154; cell differentiation
GO:6470; protein dephosphorylation
GO:6914; autophagy
GO:165; MAPK cascade
GO:46777; protein autophosphorylation
GO:7165; signal transduction
GO:42391; regulation of membrane potential
GO:70973; protein localization to endoplasmic reticulum exit site
GO:10508; positive regulation of autophagy
GO:31398; positive regulation of protein ubiquitination
GO:48812; neuron projection morphogenesis
GO:7030; Golgi organization
GO:31647; regulation of protein stability
GO:19722; calcium-mediated signaling
GO:7005; mitochondrion organization
GO:45860; positive regulation of protein kinase activity
GO:1934; positive regulation of protein phosphorylation
GO:7528; neuromuscular junction development
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:60070; canonical Wnt signaling pathway
GO:7029; endoplasmic reticulum organization
GO:7254; JNK cascade
GO:1901214; regulation of neuron death
GO:18105; peptidyl-serine phosphorylation
GO:1903206; negative regulation of hydrogen peroxide-induced cell death
GO:18107; peptidyl-threonine phosphorylation
GO:34599; cellular response to oxidative stress
GO:1901215; negative regulation of neuron death
GO:1902236; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:32092; positive regulation of protein binding
GO:60828; regulation of canonical Wnt signaling pathway
GO:71287; cellular response to manganese ion
GO:1902803; regulation of synaptic vesicle transport
GO:1903351; cellular response to dopamine
GO:61001; regulation of dendritic spine morphogenesis
GO:32091; negative regulation of protein binding
GO:1903215; negative regulation of protein targeting to mitochondrion
GO:6979; response to oxidative stress
GO:43068; positive regulation of programmed cell death
GO:8340; determination of adult lifespan
GO:10506; regulation of autophagy
GO:90140; regulation of mitochondrial fission
GO:9267; cellular response to starvation
GO:60079; excitatory postsynaptic potential
GO:46039; GTP metabolic process
GO:2000300; regulation of synaptic vesicle exocytosis
GO:51966; regulation of synaptic transmission, glutamatergic
GO:43406; positive regulation of MAP kinase activity
GO:16242; negative regulation of macroautophagy
GO:60161; positive regulation of dopamine receptor signaling pathway
GO:10955; negative regulation of protein processing
GO:35556; intracellular signal transduction
GO:60628; regulation of ER to Golgi vesicle-mediated transport
GO:6897; endocytosis
GO:1902902; negative regulation of autophagosome assembly
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:34260; negative regulation of GTPase activity
GO:1933; negative regulation of protein phosphorylation
GO:6606; protein import into nucleus
GO:7040; lysosome organization
GO:7283; spermatogenesis
GO:10468; regulation of gene expression
GO:10738; regulation of protein kinase A signaling
GO:10977; negative regulation of neuron projection development
GO:14041; regulation of neuron maturation
GO:21756; striatum development
GO:21772; olfactory bulb development
GO:22028; tangential migration from the subventricular zone to the olfactory bulb
GO:32760; positive regulation of tumor necrosis factor production
GO:34613; cellular protein localization
GO:35564; regulation of kidney size
GO:35640; exploration behavior
GO:35641; locomotory exploration behavior
GO:35751; regulation of lysosomal lumen pH
GO:40012; regulation of locomotion
GO:48312; intracellular distribution of mitochondria
GO:51646; mitochondrion localization
GO:51770; positive regulation of nitric-oxide synthase biosynthetic process
GO:51900; regulation of mitochondrial depolarization
GO:60159; regulation of dopamine receptor signaling pathway
GO:70585; protein localization to mitochondrion
GO:70997; neuron death
GO:71407; cellular response to organic cyclic compound
GO:72593; reactive oxygen species metabolic process
GO:90394; negative regulation of excitatory postsynaptic potential
GO:140058; neuron projection arborization
GO:1900242; regulation of synaptic vesicle endocytosis
GO:1900244; positive regulation of synaptic vesicle endocytosis
GO:1901727; positive regulation of histone deacetylase activity
GO:1902499; positive regulation of protein autoubiquitination
GO:1902692; regulation of neuroblast proliferation
GO:1902823; negative regulation of late endosome to lysosome transport
GO:1903125; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
GO:1903217; negative regulation of protein processing involved in protein targeting to mitochondrion
GO:1903980; positive regulation of microglial cell activation
GO:1904887; Wnt signalosome assembly
GO:1905279; regulation of retrograde transport, endosome to Golgi
GO:1905289; regulation of CAMKK-AMPK signaling cascade
GO:2000172; regulation of branching morphogenesis of a nerve
GO:2000469; negative regulation of peroxidase activity
GO:30162; regulation of proteolysis
GO:31331; positive regulation of cellular catabolic process
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:43231; intracellular membrane-bounded organelle
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5768; endosome
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5759; mitochondrial matrix
GO:5741; mitochondrial outer membrane
GO:30054; cell junction
GO:5615; extracellular space
GO:139; Golgi membrane
GO:42995; cell projection
GO:30425; dendrite
GO:5764; lysosome
GO:45202; synapse
GO:30424; axon
GO:43204; perikaryon
GO:30672; synaptic vesicle membrane
GO:5886; plasma membrane
GO:98794; postsynapse
GO:5829; cytosol
GO:70971; endoplasmic reticulum exit site
GO:70062; extracellular exosome
GO:30426; growth cone
GO:43005; neuron projection
GO:43195; terminal bouton
GO:43025; neuronal cell body
GO:1990909; Wnt signalosome
GO:32839; dendrite cytoplasm
GO:45121; membrane raft
GO:16234; inclusion body
GO:31966; mitochondrial membrane
GO:44753; amphisome
GO:44754; autolysosome
GO:5798; Golgi-associated vesicle
GO:5802; trans-Golgi network
GO:5902; microvillus
GO:8021; synaptic vesicle
GO:32473; cytoplasmic side of mitochondrial outer membrane
GO:97487; multivesicular body, internal vesicle
GO:98978; glutamatergic synapse
GO:99400; caveola neck
GO:99523; presynaptic cytosol
GO:1990904; ribonucleoprotein complex
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:16787; hydrolase activity
GO:5525; GTP binding
GO:5096; GTPase activator activity
GO:42803; protein homodimerization activity
GO:3924; GTPase activity
GO:287; magnesium ion binding
GO:42802; identical protein binding
GO:149; SNARE binding
GO:4722; protein serine/threonine phosphatase activity
GO:44325; transmembrane transporter binding
GO:30276; clathrin binding
GO:31267; small GTPase binding
GO:3779; actin binding
GO:51018; protein kinase A binding
GO:39706; co-receptor binding
GO:15631; tubulin binding
GO:8017; microtubule binding
GO:17075; syntaxin-1 binding
GO:1904713; beta-catenin destruction complex binding
GO:4706; JUN kinase kinase kinase activity
GO:4709; MAP kinase kinase kinase activity
GO:30159; signaling receptor complex adaptor activity
GO:34211; GTP-dependent protein kinase activity
GO:36479; peroxidase inhibitor activity
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Homologs of LRRK2 in Model Organisms

Danio rerio
lrrk2
Mus musculus
Lrrk2
Rattus norvegicus
Lrrk2

External links

OMIM
609007
Ensembl
ENSG00000188906
Entrez Gene
120892
UniGene
187636
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LRRK2
GeneCards
LRRK2