Cell Senescence Entries for MAD1L1

Cell Types
Myeloid lymphoma
Cell Lines
U-937
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Wu et al. (2009) TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity. Exp Cell Res 315(18)3099-111 (PubMed)

MAD1L1 Gene Information

HGNC symbol
MAD1L1 
Aliases
HsMAD1; MAD1; PIG9; TP53I9; TXBP181 
Common name
mitotic arrest deficient 1 like 1 
Entrez Id
8379
Description
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].

MAD1L1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:51301; cell division
GO:7094; mitotic spindle assembly checkpoint signaling
GO:51315; attachment of mitotic spindle microtubules to kinetochore
GO:90267; positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:90235; regulation of metaphase plate congression
GO:1902426; deactivation of mitotic spindle assembly checkpoint
GO:51220; cytoplasmic sequestering of protein
GO:42130; negative regulation of T cell proliferation
GO:48538; thymus development
GO:1901990; regulation of mitotic cell cycle phase transition
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5635; nuclear envelope
GO:5694; chromosome
GO:775; chromosome, centromeric region
GO:5815; microtubule organizing center
GO:5819; spindle
GO:776; kinetochore
GO:922; spindle pole
GO:5813; centrosome
GO:5829; cytosol
GO:72686; mitotic spindle
GO:97431; mitotic spindle pole
GO:44615; nuclear pore nuclear basket
GO:1990728; mitotic spindle assembly checkpoint MAD1-MAD2 complex
GO:1990706; MAD1 complex
GO:43229; intracellular organelle
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:43515; kinetochore binding
Hide GO terms

Homologs of MAD1L1 in Model Organisms

Caenorhabditis elegans
mdf-1
Danio rerio
mad1l1
Drosophila melanogaster
Mad1
Mus musculus
Mad1l1
Rattus norvegicus
Mad1l1
Schizosaccharomyces pombe
mad1

External links

OMIM
602686
Ensembl
ENSG00000002822
Entrez Gene
8379
UniGene
654838
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAD1L1
GeneCards
MAD1L1