Cell Senescence Entries for MAD2L1
- Cell Types
- Breast epithelial, Lung fibroblast
- Cell Lines
- IMR-90, MCF-10A
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Lentini et al. (2012) MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation. J Cell Physiol 227(9)3324-32 (PubMed)
MAD2L1 Gene Information
- HGNC symbol
- MAD2L1
- Aliases
- HSMAD2; MAD2
- Common name
- mitotic arrest deficient 2 like 1
- Entrez Id
- 4085
- Description
- MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008].
MAD2L1 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:43066; negative regulation of apoptotic process
GO:51301; cell division
GO:132; establishment of mitotic spindle orientation
GO:42177; negative regulation of protein catabolic process
GO:90267; positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:7094; mitotic spindle assembly checkpoint signaling
GO:51444; negative regulation of ubiquitin-protein transferase activity
GO:51660; establishment of centrosome localization
GO:45930; negative regulation of mitotic cell cycle
GO:70; mitotic sister chromatid segregation
GO:1904667; negative regulation of ubiquitin protein ligase activity
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5856; cytoskeleton
GO:5829; cytosol
GO:5694; chromosome
GO:48471; perinuclear region of cytoplasm
GO:775; chromosome, centromeric region
GO:776; kinetochore
GO:922; spindle pole
GO:72686; mitotic spindle
GO:44615; nuclear pore nuclear basket
GO:33597; mitotic checkpoint complex
GO:1990728; mitotic spindle assembly checkpoint MAD1-MAD2 complex
Hide GO termsFunction: GO:5515; protein binding
GO:42803; protein homodimerization activity
GO:42802; identical protein binding
GO:8022; protein C-terminus binding
Homologs of MAD2L1 in Model Organisms
- Caenorhabditis elegans
- mdf-2
- Danio rerio
- mad2l1
- Drosophila melanogaster
- mad2
- Mus musculus
- Mad2l1
- Rattus norvegicus
- Mad2l1
- Saccharomyces cerevisiae
- MAD2
- Schizosaccharomyces pombe
- mad2
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as MAD2
- CellAge gene expression
- This gene is present as MAD2L1
External links
- OMIM
- 601467
- Ensembl
- ENSG00000164109
- Entrez Gene
- 4085
- UniGene
- 591697
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MAD2L1
- GeneCards
- MAD2L1