Cell Senescence Entries for MAGEA2

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Peche et al. (2012) MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs. Cell Death Differ 19(6)926-36 (PubMed)

MAGEA2 Gene Information

HGNC symbol
MAGEA2 
Aliases
CT1.2; MAGE2; MAGEA2A 
Common name
MAGE family member A2 
Entrez Id
4101
Description
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].

MAGEA2 Ontologies

Gene Ontology
Process: GO:122; negative regulation of transcription by RNA polymerase II
GO:44257; cellular protein catabolic process
GO:90398; cellular senescence
GO:51443; positive regulation of ubiquitin-protein transferase activity
GO:33234; negative regulation of protein sumoylation
GO:72331; signal transduction by p53 class mediator
GO:1901984; negative regulation of protein acetylation
Cellular component: GO:5634; nucleus
GO:16605; PML body
Function: GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
GO:42826; histone deacetylase binding
GO:140297; DNA-binding transcription factor binding
Hide GO terms

Homologs of MAGEA2 in Model Organisms

No homologs found

External links

OMIM
300173
Ensembl
ENSG00000268606
Entrez Gene
4101
UniGene
713061
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAGEA2
GeneCards
MAGEA2