Cell Senescence Entries for MAP2K1

Cell Types
Intestinal epithelial
Cell Lines
HIEC-6
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Boucher et al. (2004) Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 286(5)G736-46 (PubMed)

MAP2K1 Gene Information

HGNC symbol
MAP2K1 
Aliases
MAPKK1; MEK1; PRKMK1 
Common name
mitogen-activated protein kinase kinase 1 
Entrez Id
5604
Description
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008].

MAP2K1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:18108; peptidyl-tyrosine phosphorylation
GO:32147; activation of protein kinase activity
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:10628; positive regulation of gene expression
GO:7507; heart development
GO:21697; cerebellar cortex formation
GO:30182; neuron differentiation
GO:30216; keratinocyte differentiation
GO:30878; thyroid gland development
GO:43410; positive regulation of MAPK cascade
GO:45597; positive regulation of cell differentiation
GO:48538; thymus development
GO:48679; regulation of axon regeneration
GO:48870; cell motility
GO:50772; positive regulation of axonogenesis
GO:60020; Bergmann glial cell differentiation
GO:60324; face development
GO:60425; lung morphogenesis
GO:60440; trachea formation
GO:60502; epithelial cell proliferation involved in lung morphogenesis
GO:60674; placenta blood vessel development
GO:60711; labyrinthine layer development
GO:70371; ERK1 and ERK2 cascade
GO:32872; regulation of stress-activated MAPK cascade
GO:90170; regulation of Golgi inheritance
GO:2000641; regulation of early endosome to late endosome transport
GO:6935; chemotaxis
GO:7165; signal transduction
GO:45893; positive regulation of transcription, DNA-templated
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:165; MAPK cascade
GO:8285; negative regulation of cell population proliferation
GO:1903800; positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:90398; cellular senescence
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5829; cytosol
GO:5886; plasma membrane
GO:5770; late endosome
GO:5739; mitochondrion
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5769; early endosome
GO:5815; microtubule organizing center
GO:5783; endoplasmic reticulum
Function: GO:5524; ATP binding
GO:4672; protein kinase activity
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:43539; protein serine/threonine kinase activator activity
GO:4708; MAP kinase kinase activity
GO:97110; scaffold protein binding
GO:8022; protein C-terminus binding
GO:30295; protein kinase activator activity
GO:5078; MAP-kinase scaffold activity
GO:47485; protein N-terminus binding
Hide GO terms

Homologs of MAP2K1 in Model Organisms

Caenorhabditis elegans
mek-2
Danio rerio
map2k1
Mus musculus
Map2k1
Rattus norvegicus
Map2k1
Schizosaccharomyces pombe
byr1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as mek-2
LongevityMap
  • This gene is present as MAP2K1

External links

OMIM
176872
Ensembl
ENSG00000169032
Entrez Gene
5604
UniGene
677223
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAP2K1
GeneCards
MAP2K1