Cell Senescence Entries for MAP2K2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Lin et al. (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 12(19)3008-19 (PubMed)

MAP2K2 Gene Information

HGNC symbol
MAP2K2 
Aliases
MEK2; PRKMK2 
Common name
mitogen-activated protein kinase kinase 2 
Entrez Id
5605
Description
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008].

MAP2K2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:18108; peptidyl-tyrosine phosphorylation
GO:43410; positive regulation of MAPK cascade
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:32872; regulation of stress-activated MAPK cascade
GO:90170; regulation of Golgi inheritance
GO:2000641; regulation of early endosome to late endosome transport
GO:45893; positive regulation of transcription, DNA-templated
GO:165; MAPK cascade
GO:1903800; positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:70371; ERK1 and ERK2 cascade
GO:36289; peptidyl-serine autophosphorylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5783; endoplasmic reticulum
GO:5770; late endosome
GO:5739; mitochondrion
GO:5576; extracellular region
GO:5925; focal adhesion
GO:5829; cytosol
GO:5874; microtubule
GO:48471; perinuclear region of cytoplasm
GO:5769; early endosome
GO:5778; peroxisomal membrane
GO:9898; cytoplasmic side of plasma membrane
GO:5911; cell-cell junction
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:43539; protein serine/threonine kinase activator activity
GO:30165; PDZ domain binding
GO:4708; MAP kinase kinase activity
GO:97110; scaffold protein binding
GO:5078; MAP-kinase scaffold activity
Hide GO terms

Homologs of MAP2K2 in Model Organisms

Danio rerio
map2k2b
Drosophila melanogaster
Dsor1
Mus musculus
Map2k2
Rattus norvegicus
Map2k2
Saccharomyces cerevisiae
STE7

External links

OMIM
601263
Ensembl
ENSG00000126934
Entrez Gene
5605
UniGene
465627
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAP2K2
GeneCards
MAP2K2