Cell Senescence Entries for MAP2K6

Cell Types
Osteosarcoma
Cell Lines
U2OS
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Haq et al. (2002) Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res 62(17)5076-82 (PubMed)

MAP2K6 Gene Information

HGNC symbol
MAP2K6 
Aliases
MAPKK6; MEK6; MKK6; PRKMK6; SAPKK3 
Common name
mitogen-activated protein kinase kinase 6 
Entrez Id
5608
Description
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008].

MAP2K6 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:18108; peptidyl-tyrosine phosphorylation
GO:165; MAPK cascade
GO:1649; osteoblast differentiation
GO:1934; positive regulation of protein phosphorylation
GO:2931; response to ischemia
GO:9410; response to xenobiotic stimulus
GO:22602; ovulation cycle process
GO:32308; positive regulation of prostaglandin secretion
GO:43065; positive regulation of apoptotic process
GO:43406; positive regulation of MAP kinase activity
GO:43410; positive regulation of MAPK cascade
GO:51770; positive regulation of nitric-oxide synthase biosynthetic process
GO:60048; cardiac muscle contraction
GO:60348; bone development
GO:72709; cellular response to sorbitol
GO:120163; negative regulation of cold-induced thermogenesis
GO:1901796; regulation of signal transduction by p53 class mediator
GO:7165; signal transduction
GO:51403; stress-activated MAPK cascade
GO:90398; cellular senescence
GO:51726; regulation of cell cycle
GO:38066; p38MAPK cascade
GO:70423; nucleotide-binding oligomerization domain containing signaling pathway
GO:6975; DNA damage induced protein phosphorylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:19901; protein kinase binding
GO:4708; MAP kinase kinase activity
GO:19211; phosphatase activator activity
GO:43539; protein serine/threonine kinase activator activity
Hide GO terms

Homologs of MAP2K6 in Model Organisms

Danio rerio
map2k6
Drosophila melanogaster
lic
Mus musculus
Map2k6
Rattus norvegicus
Map2k6

External links

OMIM
601254
Ensembl
ENSG00000108984
Entrez Gene
5608
UniGene
463978
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAP2K6
GeneCards
MAP2K6