Cell Senescence Entries for MAP3K14

Cell Types

Cervical cancer

Cell Lines

HeLa

Cancer Cell?

Yes

Method

Knockdown, Mutation

Type of senescence

Stress-induced

Senescence Effect

Induces

Primary Reference

Ho et al. (2012) HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA. J Virol 86(17)9474-83 (PubMed)

MAP3K14 Gene Information

HGNC symbol

MAP3K14 

Aliases

FTDCR1B; HS; HSNIK; NIK 

Common name

mitogen-activated protein kinase kinase kinase 14 

Entrez Id

9020

Description

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008].

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MAP3K14 Ontologies

Gene Ontology

Process:

GO:6468; protein phosphorylation GO:16310; phosphorylation GO:165; MAPK cascade GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling GO:51607; defense response to virus GO:6955; immune response GO:71260; cellular response to mechanical stimulus GO:7249; I-kappaB kinase/NF-kappaB signaling GO:38061; NIK/NF-kappaB signaling

Cellular component:

GO:5737; cytoplasm GO:43231; intracellular membrane-bounded organelle GO:5654; nucleoplasm GO:5829; cytosol GO:1650; fibrillar center

Function:

GO:166; nucleotide binding GO:4672; protein kinase activity GO:4674; protein serine/threonine kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:5524; ATP binding GO:16301; kinase activity GO:16740; transferase activity GO:106310; protein serine kinase activity GO:5515; protein binding GO:4709; MAP kinase kinase kinase activity GO:4704; NF-kappaB-inducing kinase activity

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Homologs of MAP3K14 in Model Organisms

Danio rerio

si:dkey-260c8.4

Mus musculus

Map3k14

Rattus norvegicus

Map3k14

External links

OMIM

604655

Ensembl

ENSG00000006062

Entrez Gene

9020

UniGene

668927

1000 Genomes

1000 Genomes

HPRD

GenAtlas

MAP3K14

GeneCards

MAP3K14