Cell Senescence Entries for MAP3K5

Cell Types
Umbilical vein endothelial
Cell Lines
HUVEC
Cancer Cell?
No
Method
Mutation, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Yokoi et al. (2007) Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells. Diabetes 55(6)1660-5 (PubMed)

MAP3K5 Gene Information

HGNC symbol
MAP3K5 
Aliases
ASK1; MAPKKK5; MEKK5 
Common name
mitogen-activated protein kinase kinase kinase 5 
Entrez Id
4217
Description
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008].

MAP3K5 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:2376; immune system process
GO:45087; innate immune response
GO:43065; positive regulation of apoptotic process
GO:165; MAPK cascade
GO:45860; positive regulation of protein kinase activity
GO:7254; JNK cascade
GO:90398; cellular senescence
GO:70059; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:45893; positive regulation of transcription, DNA-templated
GO:8631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:34976; response to endoplasmic reticulum stress
GO:97190; apoptotic signaling pathway
GO:43507; positive regulation of JUN kinase activity
GO:1901216; positive regulation of neuron death
GO:70301; cellular response to hydrogen peroxide
GO:43280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:34198; cellular response to amino acid starvation
GO:51403; stress-activated MAPK cascade
GO:1934; positive regulation of protein phosphorylation
GO:2931; response to ischemia
GO:10666; positive regulation of cardiac muscle cell apoptotic process
GO:10941; regulation of cell death
GO:38066; p38MAPK cascade
GO:42060; wound healing
GO:43410; positive regulation of MAPK cascade
GO:45663; positive regulation of myoblast differentiation
GO:46330; positive regulation of JNK cascade
GO:71356; cellular response to tumor necrosis factor
GO:72577; endothelial cell apoptotic process
GO:97300; programmed necrotic cell death
GO:1900745; positive regulation of p38MAPK cascade
GO:1902170; cellular response to reactive nitrogen species
GO:1904707; positive regulation of vascular associated smooth muscle cell proliferation
Cellular component: GO:5737; cytoplasm
GO:5783; endoplasmic reticulum
GO:5829; cytosol
GO:32991; protein-containing complex
GO:1990604; IRE1-TRAF2-ASK1 complex
GO:9897; external side of plasma membrane
GO:1902911; protein kinase complex
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:42803; protein homodimerization activity
GO:4709; MAP kinase kinase kinase activity
GO:287; magnesium ion binding
GO:42802; identical protein binding
GO:19904; protein domain specific binding
GO:19903; protein phosphatase binding
GO:4706; JUN kinase kinase kinase activity
GO:19901; protein kinase binding
Hide GO terms

Homologs of MAP3K5 in Model Organisms

Danio rerio
map3k5
Drosophila melanogaster
Pk92B
Mus musculus
Map3k5
Rattus norvegicus
Map3k5

In other databases

GenAge human genes
  • This gene is present as MAP3K5

External links

OMIM
602448
Ensembl
ENSG00000197442
Entrez Gene
4217
UniGene
186486
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAP3K5
GeneCards
MAP3K5