Cell Senescence Entries for MAP3K7

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

MAP3K7 Gene Information

HGNC symbol
MAP3K7 
Aliases
MEKK7; TAK1 
Common name
mitogen-activated protein kinase kinase kinase 7 
Entrez Id
6885
Description
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

MAP3K7 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:7165; signal transduction
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:165; MAPK cascade
GO:50852; T cell receptor signaling pathway
GO:7250; activation of NF-kappaB-inducing kinase activity
GO:16239; positive regulation of macroautophagy
GO:7254; JNK cascade
GO:38095; Fc-epsilon receptor signaling pathway
GO:51403; stress-activated MAPK cascade
GO:2223; stimulatory C-type lectin receptor signaling pathway
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:70498; interleukin-1-mediated signaling pathway
GO:2726; positive regulation of T cell cytokine production
GO:2753; cytoplasmic pattern recognition receptor signaling pathway
GO:2755; MyD88-dependent toll-like receptor signaling pathway
GO:7179; transforming growth factor beta receptor signaling pathway
GO:7249; I-kappaB kinase/NF-kappaB signaling
GO:7252; I-kappaB phosphorylation
GO:32743; positive regulation of interleukin-2 production
GO:38066; p38MAPK cascade
GO:43276; anoikis
GO:43507; positive regulation of JUN kinase activity
GO:43966; histone H3 acetylation
GO:70423; nucleotide-binding oligomerization domain containing signaling pathway
GO:43410; positive regulation of MAPK cascade
GO:50896; response to stimulus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:10008; endosome membrane
GO:8385; IkappaB kinase complex
GO:140672; ATAC complex
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:287; magnesium ion binding
GO:4707; MAP kinase activity
GO:42802; identical protein binding
GO:5515; protein binding
GO:4709; MAP kinase kinase kinase activity
GO:97110; scaffold protein binding
GO:8349; MAP kinase kinase kinase kinase activity
GO:30971; receptor tyrosine kinase binding
Hide GO terms

Homologs of MAP3K7 in Model Organisms

Caenorhabditis elegans
CELE_Y105C5A.24
Danio rerio
map3k7
Drosophila melanogaster
Tak1
Mus musculus
Map3k7
Rattus norvegicus
Map3k7

In other databases

LongevityMap
  • This gene is present as MAP3K7

External links

OMIM
602614
Ensembl
ENSG00000135341
Entrez Gene
6885
UniGene
594838
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAP3K7
GeneCards
MAP3K7