Cell Senescence Entries for MAPK14

Cell Types
Lung fibroblast
Cell Lines
MRC-5, WI-38
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Iwasa et al. (2003) Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 8(2)131-44 (PubMed)

MAPK14 Gene Information

HGNC symbol
MAPK14 
Aliases
CSBP1; CSBP2; CSPB1; Mxi2; p38; PRKM14; PRKM15 
Common name
mitogen-activated protein kinase 14 
Entrez Id
1432
Description
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

MAPK14 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:165; MAPK cascade
GO:6915; apoptotic process
GO:6357; regulation of transcription by RNA polymerase II
GO:38066; p38MAPK cascade
GO:35556; intracellular signal transduction
GO:98586; cellular response to virus
GO:10628; positive regulation of gene expression
GO:6935; chemotaxis
GO:7165; signal transduction
GO:32735; positive regulation of interleukin-12 production
GO:7166; cell surface receptor signaling pathway
GO:30168; platelet activation
GO:1901741; positive regulation of myoblast fusion
GO:35331; negative regulation of hippo signaling
GO:90398; cellular senescence
GO:35924; cellular response to vascular endothelial growth factor stimulus
GO:48010; vascular endothelial growth factor receptor signaling pathway
GO:30316; osteoclast differentiation
GO:18105; peptidyl-serine phosphorylation
GO:71223; cellular response to lipoteichoic acid
GO:2000379; positive regulation of reactive oxygen species metabolic process
GO:71222; cellular response to lipopolysaccharide
GO:42770; signal transduction in response to DNA damage
GO:71479; cellular response to ionizing radiation
GO:2862; negative regulation of inflammatory response to antigenic stimulus
GO:70935; 3'-UTR-mediated mRNA stabilization
GO:10831; positive regulation of myotube differentiation
GO:45663; positive regulation of myoblast differentiation
GO:45648; positive regulation of erythrocyte differentiation
GO:31281; positive regulation of cyclase activity
GO:90400; stress-induced premature senescence
GO:51149; positive regulation of muscle cell differentiation
GO:1900015; regulation of cytokine production involved in inflammatory response
GO:77; DNA damage checkpoint signaling
GO:902; cell morphogenesis
GO:1502; cartilage condensation
GO:1525; angiogenesis
GO:1649; osteoblast differentiation
GO:1890; placenta development
GO:2021; response to dietary excess
GO:2062; chondrocyte differentiation
GO:6006; glucose metabolic process
GO:6355; regulation of transcription, DNA-templated
GO:6974; cellular response to DNA damage stimulus
GO:7178; transmembrane receptor protein serine/threonine kinase signaling pathway
GO:7519; skeletal muscle tissue development
GO:19395; fatty acid oxidation
GO:30278; regulation of ossification
GO:31663; lipopolysaccharide-mediated signaling pathway
GO:32495; response to muramyl dipeptide
GO:32496; response to lipopolysaccharide
GO:32868; response to insulin
GO:35994; response to muscle stretch
GO:42307; positive regulation of protein import into nucleus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:46326; positive regulation of glucose import
GO:51146; striated muscle cell differentiation
GO:60045; positive regulation of cardiac muscle cell proliferation
GO:60348; bone development
GO:71356; cellular response to tumor necrosis factor
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:90336; positive regulation of brown fat cell differentiation
GO:99179; regulation of synaptic membrane adhesion
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16607; nuclear speck
GO:5829; cytosol
GO:5576; extracellular region
GO:5654; nucleoplasm
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
GO:922; spindle pole
GO:5739; mitochondrion
GO:98978; glutamatergic synapse
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4707; MAP kinase activity
GO:5515; protein binding
GO:19903; protein phosphatase binding
GO:19899; enzyme binding
GO:51525; NFAT protein binding
GO:4708; MAP kinase kinase activity
GO:48273; mitogen-activated protein kinase p38 binding
Hide GO terms

Homologs of MAPK14 in Model Organisms

Danio rerio
mapk14b
Mus musculus
Mapk14
Rattus norvegicus
Mapk14

In other databases

GenAge human genes
  • This gene is present as MAPK14

External links

OMIM
600289
Ensembl
ENSG00000112062
Entrez Gene
1432
UniGene
485233
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAPK14
GeneCards
MAPK14