Cell Senescence Entries for MAPKAPK5

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Sun et al. (2007) PRAK is essential for ras-induced senescence and tumor suppression. Cell 128(2)295-308 (PubMed)

MAPKAPK5 Gene Information

HGNC symbol
MAPKAPK5 
Aliases
MK5; PRAK 
Common name
MAPK activated protein kinase 5 
Entrez Id
8550
Description
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012].

MAPKAPK5 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:165; MAPK cascade
GO:6417; regulation of translation
GO:46777; protein autophosphorylation
GO:35556; intracellular signal transduction
GO:7265; Ras protein signal transduction
GO:18105; peptidyl-serine phosphorylation
GO:32007; negative regulation of TOR signaling
GO:1901796; regulation of signal transduction by p53 class mediator
GO:7165; signal transduction
GO:32212; positive regulation of telomere maintenance via telomerase
GO:51973; positive regulation of telomerase activity
GO:90398; cellular senescence
GO:1904355; positive regulation of telomere capping
GO:90400; stress-induced premature senescence
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:5516; calmodulin binding
GO:2039; p53 binding
GO:51019; mitogen-activated protein kinase binding
GO:4708; MAP kinase kinase activity
GO:4683; calmodulin-dependent protein kinase activity
GO:9931; calcium-dependent protein serine/threonine kinase activity
Hide GO terms

Homologs of MAPKAPK5 in Model Organisms

Danio rerio
mapkapk5
Mus musculus
Mapkapk5
Rattus norvegicus
Mapkapk5

External links

OMIM
606723
Ensembl
ENSG00000089022
Entrez Gene
8550
UniGene
413901
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAPKAPK5
GeneCards
MAPKAPK5