Cell Senescence Entries for MAVS

Cell Types
Bone marrow mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Gao et al. (2017) Bone Marrow-Derived Mesenchymal Stem Cells From Patients With Systemic Lupus Erythematosus Have a Senescence-Associated Secretory Phenotype Mediated by a Mitochondrial Antiviral Signaling Protein-Interferon-β Feedback Loop. Arthritis Rheumatol 69(8)1623-1635 (PubMed)

MAVS Gene Information

HGNC symbol
MAVS 
Aliases
Cardif; IPS-1; KIAA1271; VISA 
Common name
mitochondrial antiviral signaling protein 
Entrez Id
57506
Description
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral innate immunity. [provided by RefSeq, Jul 2020].

MAVS Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:42742; defense response to bacterium
GO:45071; negative regulation of viral genome replication
GO:32755; positive regulation of interleukin-6 production
GO:32760; positive regulation of tumor necrosis factor production
GO:60340; positive regulation of type I interferon-mediated signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:32727; positive regulation of interferon-alpha production
GO:32728; positive regulation of interferon-beta production
GO:32757; positive regulation of interleukin-8 production
GO:1900063; regulation of peroxisome organization
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:1934; positive regulation of protein phosphorylation
GO:2218; activation of innate immune response
GO:2230; positive regulation of defense response to virus by host
GO:71360; cellular response to exogenous dsRNA
GO:42307; positive regulation of protein import into nucleus
GO:2735; positive regulation of myeloid dendritic cell cytokine production
GO:60760; positive regulation of response to cytokine stimulus
GO:71651; positive regulation of chemokine (C-C motif) ligand 5 production
GO:71660; positive regulation of IP-10 production
GO:60337; type I interferon signaling pathway
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:5777; peroxisome
GO:31966; mitochondrial membrane
GO:5778; peroxisomal membrane
GO:151; ubiquitin ligase complex
Function: GO:5515; protein binding
GO:35591; signaling adaptor activity
GO:19901; protein kinase binding
GO:50700; CARD domain binding
Hide GO terms

Homologs of MAVS in Model Organisms

Danio rerio
mavs
Mus musculus
Mavs
Rattus norvegicus
Mavs

In other databases

LongevityMap
  • This gene is present as MAVS

External links

OMIM
609676
Ensembl
ENSG00000088888
Entrez Gene
57506
UniGene
570362
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAVS
GeneCards
MAVS