Cell Senescence Entries for MCL1

Cell Types
Colon cancer
Cell Lines
HCT116
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Bolesta et al. (2013) Inhibition of Mcl-1 promotes senescence in cancer cells: implications for preventing tumor growth and chemotherapy resistance. Mol Cell Biol 32(10)1879-92 (PubMed)

MCL1 Gene Information

HGNC symbol
MCL1 
Aliases
BCL2L3; Mcl-1 
Common name
MCL1 apoptosis regulator, BCL2 family member 
Entrez Id
4170
Description
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010].

MCL1 Ontologies

Gene Ontology
Process: GO:71806; protein transmembrane transport
GO:6915; apoptotic process
GO:42981; regulation of apoptotic process
GO:30154; cell differentiation
GO:43066; negative regulation of apoptotic process
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
GO:1709; cell fate determination
GO:10507; negative regulation of autophagy
GO:2001243; negative regulation of intrinsic apoptotic signaling pathway
GO:43065; positive regulation of apoptotic process
GO:2000811; negative regulation of anoikis
GO:34097; response to cytokine
GO:19725; cellular homeostasis
GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001020; regulation of response to DNA damage stimulus
GO:1903378; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:12501; programmed cell death
GO:80135; regulation of cellular response to stress
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:5829; cytosol
GO:5654; nucleoplasm
GO:97136; Bcl-2 family protein complex
Function: GO:5515; protein binding
GO:42803; protein homodimerization activity
GO:46982; protein heterodimerization activity
GO:8320; protein transmembrane transporter activity
GO:51434; BH3 domain binding
Hide GO terms

Homologs of MCL1 in Model Organisms

Danio rerio
mcl1a
Mus musculus
Mcl1
Rattus norvegicus
Mcl1

External links

OMIM
159552
Ensembl
ENSG00000143384
Entrez Gene
4170
UniGene
632486
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MCL1
GeneCards
MCL1