Cell Senescence Entries for MCM3AP

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Ohta et al. (2009) Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas. Cancer Sci 100(11)2069-76 (PubMed)

MCM3AP Gene Information

HGNC symbol
MCM3AP 
Aliases
GANP; KIAA0572; Map80; SAC3 
Common name
minichromosome maintenance complex component 3 associated protein 
Entrez Id
8888
Description
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014].

MCM3AP Ontologies

Gene Ontology
Process: GO:51028; mRNA transport
GO:15031; protein transport
GO:2376; immune system process
GO:16573; histone acetylation
GO:6406; mRNA export from nucleus
GO:16446; somatic hypermutation of immunoglobulin genes
GO:16973; poly(A)+ mRNA export from nucleus
GO:34728; nucleosome organization
GO:43966; histone H3 acetylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5635; nuclear envelope
GO:31965; nuclear membrane
GO:5694; chromosome
GO:5643; nuclear pore
GO:70390; transcription export complex 2
GO:44615; nuclear pore nuclear basket
Function: GO:3676; nucleic acid binding
GO:16740; transferase activity
GO:16746; acyltransferase activity
GO:4402; histone acetyltransferase activity
GO:5515; protein binding
GO:3682; chromatin binding
GO:42393; histone binding
GO:10484; H3 histone acetyltransferase activity
Hide GO terms

Homologs of MCM3AP in Model Organisms

Danio rerio
mcm3ap
Drosophila melanogaster
xmas-2
Mus musculus
Mcm3ap
Rattus norvegicus
Mcm3ap

External links

OMIM
603294
Ensembl
ENSG00000160294
Entrez Gene
8888
UniGene
592438
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MCM3AP
GeneCards
MCM3AP