Cell Senescence Entries for MCRS1

Cell Types
Foreskin fibroblast, Lung fibroblast, Mammary epithelial
Cell Lines
H184B5F5/M10, HS68, IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Hsu et al. (2012) 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. J Biol Chem 287(27)22533-48 (PubMed)

MCRS1 Gene Information

HGNC symbol
MCRS1 
Aliases
ICP22BP; INO80Q; MCRS2; MSP58; P78 
Common name
microspherule protein 1 
Entrez Id
10445
Description

MCRS1 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6310; DNA recombination
GO:45944; positive regulation of transcription by RNA polymerase II
GO:43981; histone H4-K5 acetylation
GO:43982; histone H4-K8 acetylation
GO:6464; cellular protein modification process
GO:45893; positive regulation of transcription, DNA-templated
GO:43984; histone H4-K16 acetylation
GO:51571; positive regulation of histone H3-K4 methylation
GO:6275; regulation of DNA replication
GO:6338; chromatin remodeling
GO:42766; nucleosome mobilization
GO:51726; regulation of cell cycle
GO:33044; regulation of chromosome organization
GO:60382; regulation of DNA strand elongation
GO:45739; positive regulation of DNA repair
GO:723; telomere maintenance
GO:6282; regulation of DNA repair
GO:45995; regulation of embryonic development
GO:1900095; regulation of dosage compensation by inactivation of X chromosome
GO:1904507; positive regulation of telomere maintenance in response to DNA damage
GO:1904751; positive regulation of protein localization to nucleolus
GO:1904357; negative regulation of telomere maintenance via telomere lengthening
GO:51974; negative regulation of telomerase activity
Cellular component: GO:31011; Ino80 complex
GO:71339; MLL1 complex
GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:30425; dendrite
GO:123; histone acetyltransferase complex
GO:43204; perikaryon
GO:44545; NSL complex
GO:5844; polysome
GO:5783; endoplasmic reticulum
Function: GO:2151; G-quadruplex RNA binding
GO:5515; protein binding
GO:34046; poly(G) binding
GO:8266; poly(U) RNA binding
GO:10521; telomerase inhibitor activity
Hide GO terms

Homologs of MCRS1 in Model Organisms

Caenorhabditis elegans
mcrs-1
Danio rerio
mcrs1
Drosophila melanogaster
Rcd5
Mus musculus
Mcrs1
Rattus norvegicus
Mcrs1

External links

OMIM
609504
Ensembl
ENSG00000187778
Entrez Gene
10445
UniGene
25313
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MCRS1
GeneCards
MCRS1