Cell Senescence Entries for MCU

Cell Types
Endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wiel et al. (2016) Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence. Nat Commun 5(2)3792 (PubMed)

MCU Gene Information

HGNC symbol
MCU 
Aliases
C10orf42; CCDC109A; FLJ46135 
Common name
mitochondrial calcium uniporter 
Entrez Id
90550
Description
This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].

MCU Ontologies

Gene Ontology
Process: GO:6811; ion transport
GO:6816; calcium ion transport
GO:70588; calcium ion transmembrane transport
GO:19722; calcium-mediated signaling
GO:51259; protein complex oligomerization
GO:90023; positive regulation of neutrophil chemotaxis
GO:42593; glucose homeostasis
GO:32024; positive regulation of insulin secretion
GO:6851; mitochondrial calcium ion transmembrane transport
GO:51560; mitochondrial calcium ion homeostasis
GO:51561; positive regulation of mitochondrial calcium ion concentration
GO:90141; positive regulation of mitochondrial fission
GO:36444; calcium import into the mitochondrion
GO:90527; actin filament reorganization
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:31305; integral component of mitochondrial inner membrane
GO:34704; calcium channel complex
GO:1990246; uniplex complex
Function: GO:5515; protein binding
GO:5262; calcium channel activity
GO:42802; identical protein binding
GO:15292; uniporter activity
Hide GO terms

Homologs of MCU in Model Organisms

Danio rerio
mcu
Drosophila melanogaster
CG18769
Mus musculus
Mcu
Rattus norvegicus
Mcu

External links

OMIM
614197
Ensembl
ENSG00000156026
Entrez Gene
90550
UniGene
591366
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MCU
GeneCards
MCU