The MDC1 gene and its putative association with human ageing

Cell Senescence Entries for MDC1

Cell Types: Lung fibroblast
Cell Lines: IMR-90
Cancer Cell?: Yes
Method: Knockdown
Type of senescence: Replicative
Senescence Effect: Inhibits
Primary Reference: Dimitrova et al. (2007) MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev 20(23)3238-43 (PubMed)

HGNC symbol: MDC1
Aliases: Em:AB023051.5; KIAA0170; NFBD1
Common name: mediator of DNA damage checkpoint 1
Entrez Id: 9656
Description: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008].

Gene Ontology

Process:

GO:7049; cell cycle
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:31573; mitotic intra-S DNA damage checkpoint signaling

Cellular component:

GO:5634; nucleus
GO:5654; nucleoplasm
GO:5925; focal adhesion
GO:5694; chromosome
GO:16604; nuclear body
GO:43229; intracellular organelle

Function:

GO:5515; protein binding
GO:8022; protein C-terminus binding
GO:70975; FHA domain binding

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