Cell Senescence Entries for MDK

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Liu et al. (2020) A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. Aging (Albany NY) 11(12)4011-4031 (PubMed)

MDK Gene Information

HGNC symbol
MDK 
Aliases
FLJ27379; MK; NEGF2 
Common name
midkine 
Entrez Id
4192
Description
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012].

MDK Ontologies

Gene Ontology
Process: GO:30154; cell differentiation
GO:7399; nervous system development
GO:7010; cytoskeleton organization
GO:51781; positive regulation of cell division
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:2001224; positive regulation of neuron migration
GO:30335; positive regulation of cell migration
GO:50729; positive regulation of inflammatory response
GO:2000179; positive regulation of neural precursor cell proliferation
GO:48477; oogenesis
GO:43524; negative regulation of neuron apoptotic process
GO:7165; signal transduction
GO:32735; positive regulation of interleukin-12 production
GO:45785; positive regulation of cell adhesion
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:7162; negative regulation of cell adhesion
GO:10759; positive regulation of macrophage chemotaxis
GO:2000249; regulation of actin cytoskeleton reorganization
GO:10838; positive regulation of keratinocyte proliferation
GO:2232; leukocyte chemotaxis involved in inflammatory response
GO:10976; positive regulation of neuron projection development
GO:46850; regulation of bone remodeling
GO:9611; response to wounding
GO:10667; negative regulation of cardiac muscle cell apoptotic process
GO:1904036; negative regulation of epithelial cell apoptotic process
GO:30279; negative regulation of ossification
GO:106091; glial cell projection elongation
GO:1900026; positive regulation of substrate adhesion-dependent cell spreading
GO:30325; adrenal gland development
GO:42246; tissue regeneration
GO:1904996; positive regulation of leukocyte adhesion to vascular endothelial cell
GO:45582; positive regulation of T cell differentiation
GO:2000347; positive regulation of hepatocyte proliferation
GO:45590; negative regulation of regulatory T cell differentiation
GO:2286; T cell activation involved in immune response
GO:90023; positive regulation of neutrophil chemotaxis
GO:44849; estrous cycle
GO:2690; positive regulation of leukocyte chemotaxis
GO:10996; response to auditory stimulus
GO:48714; positive regulation of oligodendrocyte differentiation
GO:32330; regulation of chondrocyte differentiation
GO:61036; positive regulation of cartilage development
GO:71673; positive regulation of smooth muscle cell chemotaxis
GO:106015; negative regulation of inflammatory response to wounding
GO:106016; positive regulation of inflammatory response to wounding
GO:1903039; positive regulation of leukocyte cell-cell adhesion
GO:1905555; positive regulation of blood vessel branching
GO:1905564; positive regulation of vascular endothelial cell proliferation
GO:1905653; positive regulation of artery morphogenesis
GO:2000391; positive regulation of neutrophil extravasation
GO:50896; response to stimulus
GO:1662; behavioral fear response
GO:7614; short-term memory
GO:9410; response to xenobiotic stimulus
GO:9725; response to hormone
GO:16477; cell migration
GO:21542; dentate gyrus development
GO:21681; cerebellar granular layer development
GO:21766; hippocampus development
GO:21987; cerebral cortex development
GO:30421; defecation
GO:45893; positive regulation of transcription, DNA-templated
GO:50795; regulation of behavior
GO:51384; response to glucocorticoid
GO:1901215; negative regulation of neuron death
Cellular component: GO:5576; extracellular region
GO:62023; collagen-containing extracellular matrix
GO:5737; cytoplasm
GO:42995; cell projection
Function: GO:8083; growth factor activity
GO:5515; protein binding
GO:8201; heparin binding
GO:35374; chondroitin sulfate binding
GO:1904399; heparan sulfate binding
Hide GO terms

Homologs of MDK in Model Organisms

Danio rerio
mdkb
Mus musculus
Mdk
Rattus norvegicus
Mdk

In other databases

CellAge gene expression
  • This gene is present as MDK

External links

OMIM
162096
Ensembl
ENSG00000110492
Entrez Gene
4192
UniGene
82045
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MDK
GeneCards
MDK