Cell Senescence Entries for MEF2A

Cell Types
Umbilical vein endothelial
Cell Lines
HUVEC
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Liu et al. (2020) Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. Aging (Albany NY) 11(11)3768-3784 (PubMed)

MEF2A Gene Information

HGNC symbol
MEF2A 
Aliases
RSRFC4; RSRFC9 
Common name
myocyte enhancer factor 2A 
Entrez Id
4205
Description
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010].

MEF2A Ontologies

Gene Ontology
Process: GO:45893; positive regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48513; animal organ development
GO:6915; apoptotic process
GO:30154; cell differentiation
GO:7517; muscle organ development
GO:122; negative regulation of transcription by RNA polymerase II
GO:7399; nervous system development
GO:165; MAPK cascade
GO:6351; transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:7507; heart development
GO:71277; cellular response to calcium ion
GO:2; mitochondrial genome maintenance
GO:48813; dendrite morphogenesis
GO:10613; positive regulation of cardiac muscle hypertrophy
GO:48311; mitochondrion distribution
GO:55005; ventricular cardiac myofibril assembly
GO:61337; cardiac conduction
GO:70375; ERK5 cascade
GO:6355; regulation of transcription, DNA-templated
GO:10628; positive regulation of gene expression
GO:46326; positive regulation of glucose import
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:5667; transcription regulator complex
GO:43229; intracellular organelle
Function: GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:5515; protein binding
GO:43565; sequence-specific DNA binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:42826; histone deacetylase binding
GO:140297; DNA-binding transcription factor binding
GO:3682; chromatin binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:46982; protein heterodimerization activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:3700; DNA-binding transcription factor activity
GO:35035; histone acetyltransferase binding
GO:46332; SMAD binding
GO:19901; protein kinase binding
Hide GO terms

Homologs of MEF2A in Model Organisms

Danio rerio
mef2aa
Mus musculus
Mef2a
Rattus norvegicus
Mef2a

External links

OMIM
600660
Ensembl
ENSG00000068305
Entrez Gene
4205
UniGene
268675
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MEF2A
GeneCards
MEF2A