Cell Senescence Entries for MEN1

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wajapeyee et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132(3)363-74 (PubMed)

MEN1 Gene Information

HGNC symbol
MEN1 
Aliases
 
Common name
menin 1 
Entrez Id
4221
Description
This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019].

MEN1 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:165; MAPK cascade
GO:6357; regulation of transcription by RNA polymerase II
GO:45786; negative regulation of cell cycle
GO:8285; negative regulation of cell population proliferation
GO:51568; histone H3-K4 methylation
GO:1933; negative regulation of protein phosphorylation
GO:2076; osteoblast development
GO:45668; negative regulation of osteoblast differentiation
GO:9411; response to UV
GO:10332; response to gamma radiation
GO:30511; positive regulation of transforming growth factor beta receptor signaling pathway
GO:32092; positive regulation of protein binding
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:46329; negative regulation of JNK cascade
GO:51974; negative regulation of telomerase activity
GO:278; mitotic cell cycle
GO:3309; type B pancreatic cell differentiation
GO:7420; brain development
GO:10812; negative regulation of cell-substrate adhesion
GO:32925; regulation of activin receptor signaling pathway
GO:46697; decidualization
GO:50680; negative regulation of epithelial cell proliferation
GO:61469; regulation of type B pancreatic cell proliferation
GO:71333; cellular response to glucose stimulus
GO:71375; cellular response to peptide hormone stimulus
GO:71559; response to transforming growth factor beta
GO:1902807; negative regulation of cell cycle G1/S phase transition
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:781; chromosome, telomeric region
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:785; chromatin
GO:32154; cleavage furrow
GO:16363; nuclear matrix
GO:5788; endoplasmic reticulum lumen
GO:17053; transcription repressor complex
GO:44665; MLL1/2 complex
GO:71339; MLL1 complex
GO:35097; histone methyltransferase complex
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:3682; chromatin binding
GO:976; transcription cis-regulatory region binding
GO:3690; double-stranded DNA binding
GO:47485; protein N-terminus binding
GO:400; four-way junction DNA binding
GO:403; Y-form DNA binding
GO:30674; protein-macromolecule adaptor activity
GO:51219; phosphoprotein binding
GO:70412; R-SMAD binding
Hide GO terms

Homologs of MEN1 in Model Organisms

Danio rerio
men1
Drosophila melanogaster
Mnn1
Mus musculus
Men1
Rattus norvegicus
Men1

External links

OMIM
613733
Ensembl
ENSG00000133895
Entrez Gene
4221
UniGene
423348
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MEN1
GeneCards
MEN1