Cell Senescence Entries for MET

Cell Types
Glioma
Cell Lines
U343
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2016) Adenovirus expressing dual c-Met-specific shRNA exhibits potent antitumor effect through autophagic cell death accompanied by senescence-like phenotypes in glioblastoma cells. Oncotarget 6(6)4051-65 (PubMed)

MET Gene Information

HGNC symbol
MET 
Aliases
DFNB97; HGFR; RCCP2 
Common name
MET proto-oncogene, receptor tyrosine kinase 
Entrez Id
4233
Description
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016].

MET Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:18108; peptidyl-tyrosine phosphorylation
GO:50896; response to stimulus
GO:71526; semaphorin-plexin signaling pathway
GO:7166; cell surface receptor signaling pathway
GO:7399; nervous system development
GO:16477; cell migration
GO:10507; negative regulation of autophagy
GO:30182; neuron differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:7165; signal transduction
GO:33674; positive regulation of kinase activity
GO:48754; branching morphogenesis of an epithelial tube
GO:50918; positive chemotaxis
GO:51897; positive regulation of protein kinase B signaling
GO:6909; phagocytosis
GO:1886; endothelial cell morphogenesis
GO:1889; liver development
GO:31016; pancreas development
GO:31116; positive regulation of microtubule polymerization
GO:35024; negative regulation of Rho protein signal transduction
GO:48012; hepatocyte growth factor receptor signaling pathway
GO:51497; negative regulation of stress fiber assembly
GO:61436; establishment of skin barrier
GO:70495; negative regulation of thrombin-activated receptor signaling pathway
GO:1901299; negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1905098; negative regulation of guanyl-nucleotide exchange factor activity
GO:2001028; positive regulation of endothelial cell chemotaxis
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5576; extracellular region
GO:9986; cell surface
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
GO:43235; receptor complex
GO:9925; basal plasma membrane
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5515; protein binding
GO:17154; semaphorin receptor activity
GO:42802; identical protein binding
GO:19903; protein phosphatase binding
GO:5008; hepatocyte growth factor-activated receptor activity
Hide GO terms

Homologs of MET in Model Organisms

Danio rerio
met
Mus musculus
Met
Rattus norvegicus
Met

External links

OMIM
164860
Ensembl
ENSG00000105976
Entrez Gene
4233
UniGene
132966
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MET
GeneCards
MET