Cell Senescence Entries for METTL14
- Cell Types
- Cervical cancer, Colon cancer
- Cell Lines
- HCT116, HeLa
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Li et al. (2017) NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation. J Cell Biochem 118(9)2587-2598 (PubMed)
METTL14 Gene Information
- HGNC symbol
- METTL14
- Aliases
- KIAA1627
- Common name
- methyltransferase 14, N6-adenosine-methyltransferase subunit
- Entrez Id
- 57721
- Description
METTL14 Ontologies
- Gene Ontology
-
Process: GO:30154; cell differentiation
GO:398; mRNA splicing, via spliceosome
GO:7283; spermatogenesis
GO:80009; mRNA methylation
GO:19827; stem cell population maintenance
GO:42063; gliogenesis
GO:1901533; negative regulation of hematopoietic progenitor cell differentiation
GO:61157; mRNA destabilization
GO:21861; forebrain radial glial cell differentiation
GO:1510; RNA methylation
GO:6402; mRNA catabolic process
GO:45727; positive regulation of translation
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:36396; RNA N6-methyladenosine methyltransferase complex
Hide GO termsFunction: GO:3723; RNA binding
GO:5515; protein binding
GO:3729; mRNA binding
GO:16422; mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
GO:8757; S-adenosylmethionine-dependent methyltransferase activity
Homologs of METTL14 in Model Organisms
- Danio rerio
- mettl14
- Drosophila melanogaster
- CG7818
- Mus musculus
- Mettl14
- Rattus norvegicus
- Mettl14
- Saccharomyces cerevisiae
- KAR4
External links
- OMIM
- 616504
- Ensembl
- ENSG00000145388
- Entrez Gene
- 57721
- UniGene
- 657806
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- METTL14
- GeneCards
- METTL14