Cell Senescence Entries for MITF

Cell Types
Melanoma
Cell Lines
ST-Mel
Cancer Cell?
Yes
Method
Mutation
Type of senescence
Oncogene-induced
Senescence Effect
Unclear
Primary Reference
Bonet et al. (2017) Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression. J Natl Cancer Inst 109(8)117-26 (PubMed)

MITF Gene Information

HGNC symbol
MITF 
Aliases
bHLHe32; MI; WS2; WS2A 
Common name
melanocyte inducing transcription factor 
Entrez Id
4286
Description
The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017].

MITF Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:10628; positive regulation of gene expression
GO:65003; protein-containing complex assembly
GO:30336; negative regulation of cell migration
GO:10468; regulation of gene expression
GO:16055; Wnt signaling pathway
GO:30154; cell differentiation
GO:30316; osteoclast differentiation
GO:30318; melanocyte differentiation
GO:42127; regulation of cell population proliferation
GO:43010; camera-type eye development
GO:43066; negative regulation of apoptotic process
GO:43473; pigmentation
GO:44336; canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:45165; cell fate commitment
GO:45670; regulation of osteoclast differentiation
GO:46849; bone remodeling
GO:2000144; positive regulation of DNA-templated transcription, initiation
GO:2001141; regulation of RNA biosynthetic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:3700; DNA-binding transcription factor activity
GO:46983; protein dimerization activity
GO:3677; DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:70888; E-box binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:3682; chromatin binding
Hide GO terms

Homologs of MITF in Model Organisms

Danio rerio
mitfb
Mus musculus
Mitf

External links

OMIM
156845
Ensembl
ENSG00000187098
Entrez Gene
4286
UniGene
618266
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MITF
GeneCards
MITF